THE ESTIMATION OF THE ACTIVITY OF THE CHOLINERGIC RECEPTORS OF THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY THE COMPUTED DERMOGRAPHY METHOD

Abstract

The main aspect in treatment of the patients with chronic obstructive pulmonary disease (COPD) is the detecting of the progressing bronchoobstruction (BO). The detecting of BO is carried out by such well-known methods as spirography and peakflowmetry. Some investigators emphasized insufficient evidence of these methods that is connected with subjectivism under realization of the research. The up-to-date methods must be objective, uninvasive, economical and easy. One of such methods is the computed dermography (CD-method) developed in Primorsky region and recommended by the Department of Health for application in medical practice. From the beginning of 2004 in Russia the new preparation of anticholinergic group of prolonged action — tiotropium bromide was registered. The purpose of this research was a clinicial-functional estimation of the efficiency of the tiotropium bromide (activity cholinergic receptors) in the patients with COPD of the CD-method of the function F5-3. 20 patients with COPD III-IV stages with clinical manifestations of the COPD has been had necessary therapy according to the stage of weight were observed in Regional pulmonary center. So, the CD-method was determined to be an objective and more sensitive method which allows detecting of the BO's progressing and prognosticate it in the patients with COPD after the long treatment tiotropium bromide.