THE DYNAMICS OF THE CYTOKINES AS ONE OF PATHOGENETIC FACTORS OF THE SURGICAL SEPSIS WITH MULTI-ORGAN INSUFFICIENCY
Abstract
Immune changes at surgical patients with a sepsis and multi-organ insufficiency are investigated. It is shown; that the development of the immune deficiency after surgeries are connected to development of a syndrome of system inflammatory reaction, immune regulation changes processes at a level of differentiation of T-helpers. The ratio of y-interferon and IL-10 at different stages of sepsis is investigated. The interrelation of this parameter c by a various degree of organ dysfunction is shown (used scale SOFA), depending on ronkoleukin therapy.
About the Authors
V. A. Lazanovich
Vladivostok State Medical University;
Vladivostok branch of the Scientific Center of Reconstructive and Regenerative Surgery of the National Scientific Center;
Siberian Branch of the Russian Academy of Medical Science;
Primorsky Regional Hospital № 1
Russian Federation
Vladivostok
Russian Federation
Vladivostok
G. A. Smirnov
Vladivostok State Medical University;
Vladivostok branch of the Scientific Center of Reconstructive and Regenerative Surgery of the National Scientific Center;
Siberian Branch of the Russian Academy of Medical Science;
Primorsky Regional Hospital № 1
Russian Federation
Vladivostok
Russian Federation
Vladivostok
V. N. Ishchenko
Vladivostok State Medical University;
Vladivostok branch of the Scientific Center of Reconstructive and Regenerative Surgery of the National Scientific Center;
Siberian Branch of the Russian Academy of Medical Science;
Primorsky Regional Hospital № 1
Russian Federation
Vladivostok
Russian Federation
Vladivostok
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Review
For citations:
Lazanovich V.A., Smirnov G.A., Ishchenko V.N. THE DYNAMICS OF THE CYTOKINES AS ONE OF PATHOGENETIC FACTORS OF THE SURGICAL SEPSIS WITH MULTI-ORGAN INSUFFICIENCY. Pacific Medical Journal. 2005;(4):50-52. (In Russ.)
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