GENETIC ASPECTS OF OSTEOPOROSIS
Abstract
This paper provides a literature review on a role of genetic factors in developing osteoporosis. The authors give data on the current investigations of genes that encode vitamin D receptors and I type collagen metabolism, and their effect on mineral bone density. They also highlight that the testing of genes-candidates responsible for pre-osteoporosis provides insight into early pre-clinical detection of patients who are very likely to risk getting this disease in various forms.
About the Authors
E. A. Kochetkova
Vladivostok State Medical University; Vladivostok Branch of Research Centre of Medical Genetics (Tomsk Research Centre of the Siberian Branch of RAMS)
Russian Federation
Russian Federation
O. Yu. Bubnov
Vladivostok State Medical University; Vladivostok Branch of Research Centre of Medical Genetics (Tomsk Research Centre of the Siberian Branch of RAMS)
Russian Federation
Russian Federation
T. G. Vasilieva
Vladivostok State Medical University; Vladivostok Branch of Research Centre of Medical Genetics (Tomsk Research Centre of the Siberian Branch of RAMS)
Russian Federation
Russian Federation
O. A. Belykh
Vladivostok State Medical University; Vladivostok Branch of Research Centre of Medical Genetics (Tomsk Research Centre of the Siberian Branch of RAMS)
Russian Federation
Russian Federation
References
1. Зазерская И.Е., Асеев М.В., Кузнецова Л.В. //Остеопороз и остеопатии. — 2002. — № 2. — С. 2—6.
2. Короткова Т.А. // Остеопороз и остеопатии. — 2004. -№3.- С. 34-37.
3. Крылов М.Ю., Мякоткин В.А., Беневоленская Л.И. //Материалы I Российского конгресса по остеопорозу. - 2003. - С. 30.
4. Мякоткин В.А. // Материалы I Российского конгресса по остеопорозу. — 2003. — С. 27—29.
5. Beavan S.//Lancet. - 1996. - Vol. 348. - P. 136-137.
6. Dawson P.A.//J. Bone Miner. Res. - 1999. - Vol. 14. - P. 449-455.
7. Efstathiadou Z.//J. Bone Miner. Res. - 2001. - Vol. 16, No. 9. - P. 1586-1592.
8. Fiona E.A., Charlotte E. // J. Bone Miner. Res. — 2002. - Vol. 17. - P. 1273-1279.
9. Fox K.M., Cummings S.R. //Osteoporosis Int. — 1998. — Vol. 8, No. 6. - P. 557-562.
10. Gasrnero P., Arden N.K., Griffits G. et al. //J. Clin. Endocrinol. Metab. - 1996. - Vol. 81. - P. 140-146.
11. Gong G., Stern H.S., Cheng S.C. et al. // Osteoporosis Int. - 1999. - Vol. 9. - P. 55-64.
12. Gowen M., Wood D.D., Ihrie E.J. et al. // Nature - 1983. - Vol. 306. - P. 378-380.
13. Grant S.F., Reid D.M., Blake G.//Nat Genet. - 1996. - Vol. 14, No. 2. - P. 203-205.
14. Harris S.S., Nguyen T. V., Kelly P.J. //Bone. - 1998. - Vol. 22. - P. 141-145.
15. Harris S.S., Pettel M.S., Cole D.E.C. et al. // Calcif. Tissue Int. - 2000. - Vol. 66. - P. 268-271.
16. Hobson E., Dean V., Grant S.F.A. //J. Med. Genet. - 1998. - Vol. 35. - P. 32-37.
17. Keen R.W., Baker J.R., Kelly P.J. et al. // Bone. - 1998. - Vol. 23, No. 5(Suppl.). - P. 274.
18. Koller E.L., Rodriguez L.A., Christian 1С. et al. //J. Bone Miner. Res. - 1998. - Vol. 13. - P. 1903-1908.
19. MacDonald H.M., McGuigan F.A., New S.A. et al.//J. Bone Miner. Res. - 2001. - Vol. 16, No. 9.-P. 1634-1641.
20. Mora S., Pitukcheewanont P., Kaufman F.R. // J. Bone Miner. Res. - 1999. - No. 14. - P. 271-275.
21. Morrison N.A., Tokita J.C., Kelly P.J. // Natur. - 1994. - Vol. 367. - P. 284-287.
22. Ralston S.H. //Bone. - 1999. - Vol. 25, No. 1. - P. 85-86.
23. Slemenda С W., Christian J.C. //J. Bone Miner. Res. - 1991. - Vol. 6. - P. 561-567.
24. Slemenda C.W., Miller J.Z., Hui S.L. et al. //J. Bone Miner. Res. - 1991. - Vol. 6. - P. 1227-1233.
25. Welten D.C., Kemper H.C.G., Post G.B. et al. // J. Bone Miner. Res. - 1994. - Vol. 9. - P. 1089-1096.
Review
For citations:
Kochetkova E.A., Bubnov O.Yu., Vasilieva T.G., Belykh O.A. GENETIC ASPECTS OF OSTEOPOROSIS. Pacific Medical Journal. 2005;(2):14-17. (In Russ.)
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