STATE OF VASCULAR ENDOTHELIUM FUNCTION AND CHRONICAL INFLAMMATION IN COPD
Abstract
The authors have examined 82 patients with COPD exacerbation and 20 healthy persons. Endothelium vasomotor activity was investigated by using high-resolution ultrasound and NO metabolites content was measured in the blood serum by Greiss's method. Plasma TNF-a, IL-13 and IL-10 levels were determined by the immune-enzyme analysis, spectrophotometric method was used by measuring malonyldialdehyde and superoxide desmutase activity rate. According to the findings, COPD patients had the vasomotor and NO-generating endothelium function breach against a background of the high-powered proinflammatory response and oxidative imbalance. The correlational analysis suggested that there were interrelations of vascular endothelium dysfunction with the processes of chronic inflammation in COPD.
About the Authors
E. V. Motkina
Vladivostok State Medical University
Russian Federation
Russian Federation
V. A. Nevzorova
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Motkina E.V., Nevzorova V.A. STATE OF VASCULAR ENDOTHELIUM FUNCTION AND CHRONICAL INFLAMMATION IN COPD. Pacific Medical Journal. 2005;(2):34-37. (In Russ.)
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