ANALYSIS RELATIONSHIP OF GENE-CANDIDATES VDR3 AND COL1A1 WITH BONE METABOLISM'S MARKERS IN ADOLESCENCES WITH CARRIAGE DISORDERS
Abstract
Objective of study was to study relation of VDR and COL1A1 gene's polymorphism in adolescences with carriage dis-orders. We investigated 45 adolescences with carriage disorders. Condition of bone metabolism was estimated on blood osteocal-cini (OC) and вCrossLaps (вCL) concentration by immunoas-say method. BsmI polymorphism of length of restrictive fraction VDR3 (genotypes BB, Bb, bb) and Sp1 polymorphism COL1A1 (genotypes SS, Ss, ss) was studied using PCR. Control group was consisted by 40 health adolescences similar ages and a sex. We discovered significant different between average indices of OC level in adolescences with carriage disorders with genotypes BB, Bb and bb (BsmI-polymorphism). The difference between CL levels is found only for SS and ss genotypes. Conclusion: a poly-morphism VDR3 and COL1A1 gene has intimately relation with bone metabolism markers in adolescences with carriage disor-ders and it is key genes in development of osteopenic syndrome.
About the Authors
E. A. Kochetkova
Vladivostok department of Tomsk Institute Medical Genetic Siberian Branch of Russia Academia of Medical Sciences
Russian Federation
Russian Federation
B. I. Geltser
Vladivostok department of Tomsk Institute Medical Genetic Siberian Branch of Russia Academia of Medical Sciences
Russian Federation
Russian Federation
O. Y. Bubnov
Vladivostok department of Tomsk Institute Medical Genetic Siberian Branch of Russia Academia of Medical Sciences
Russian Federation
Russian Federation
T. G. Vasileva
Vladivostok department of Tomsk Institute Medical Genetic Siberian Branch of Russia Academia of Medical Sciences
Russian Federation
Russian Federation
O. A. Beluh
Vladivostok department of Tomsk Institute Medical Genetic Siberian Branch of Russia Academia of Medical Sciences
Russian Federation
Russian Federation
P. A. Lukyanov
Vladivostok department of Tomsk Institute Medical Genetic Siberian Branch of Russia Academia of Medical Sciences
Russian Federation
Russian Federation
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Review
For citations:
Kochetkova E.A., Geltser B.I., Bubnov O.Y., Vasileva T.G., Beluh O.A., Lukyanov P.A. ANALYSIS RELATIONSHIP OF GENE-CANDIDATES VDR3 AND COL1A1 WITH BONE METABOLISM'S MARKERS IN ADOLESCENCES WITH CARRIAGE DISORDERS. Pacific Medical Journal. 2005;(1):34-37. (In Russ.)
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