CENTRAL NITROXIDE-DEPENDENT MECHANISMS OF ANALGESIA AND PRONOCICEPTION
Abstract
Based on the literature data and his own findings, the author provides an analysis of central nitroxide mechanisms of pain sensitivity regulation. In anti-pain system a nitroxide signal serves as integrating element, producing an effect on the activity of serotonergic, noradrenergic and opiate components of endog-enous analgesia. Changes in nitrogen oxide production within "analgetic" centers of brain that occur due to the nociceptive stimulation are capable of determining the course of descending pain-modulating processes. Depending on the pain process, stage nitroxide mechanisms intensify effectiveness of either anti-pain or pronociceptive systems, thus, changing threshold of pain sensitivity.
About the Author
I. V. Dyuisen
Vladivostok State Medical University; Institute of Marine Biology of DVO RAN (Vladivostok)
Russian Federation
Russian Federation
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Review
For citations:
Dyuisen I.V. CENTRAL NITROXIDE-DEPENDENT MECHANISMS OF ANALGESIA AND PRONOCICEPTION. Pacific Medical Journal. 2004;(4):5-10. (In Russ.)
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