EFFECT OF KETONAL ON NITRIC OXIDE-FORMING ACTIVITY OF NOCICEPTIVE NEURONS IN SPINAL GANGLIONS AND SPINAL CORD
Abstract
Modelling of pain syndrome and giving of intramus-cular injection of Ketonal as for laboratory rats have allowed studying changes in the activity of nitric oxide-forming neurons of cerebrospinal ganglions and posterior horns, which are con-sidered to be "pain gates", from the standpoint of the modern science. Intramuscular injection of Ketonal resulted in suppress-ing of nitric oxide generation by nociceptive neurons of spinal ganglions and spinal cord. Mechanism of analgesic action of Ke-tonal has both peripheral and central components.
About the Authors
V. B. Shumatov
Vladivostok State Medical University
Russian Federation
Russian Federation
P. V. Dunts
Vladivostok State Medical University
Russian Federation
Russian Federation
D. N. Emelian
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Shumatov V.B., Dunts P.V., Emelian D.N. EFFECT OF KETONAL ON NITRIC OXIDE-FORMING ACTIVITY OF NOCICEPTIVE NEURONS IN SPINAL GANGLIONS AND SPINAL CORD. Pacific Medical Journal. 2004;(4):35-37. (In Russ.)
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