The frequency of alleles and genotypes of polymorphism of C-reactive protein gene in women with ischemic heart disease and postmenopausal osteoporosis
https://doi.org/10.17238/PmJ1609-1175.2017.4.65-68
Abstract
Objective. Aim: to study the frequency of alleles and genotypes of polymorphisms of the C-reactive protein (CRP) gene (С1444Т, С1846Т; С3872Т; A717G) in women with ischemic heart disease (IHD) and osteoporosis. Methods. 205 postmenopausal women aged from 60 to 76 years, living in the Trans-Baikal Territory, Russian nationality were examined. In 162 women, the diagnosis of IHD was verified, among them 76 postmenopausal osteoporosis (the first clinical group) was detected. 86 women with IHD (without osteoporosis) made up the second clinical group. 43 women of the control group did not have a risk of cardiovascular diseases and osteoporosis. Molecular genetic investigation was performed by polymerase chain reaction. Results. A statistically significant difference in the distribution of alleles and genotypes for CRP polymorphisms: C3872T and C1444T was found in women with IHD comparison with healthy individuals. The T allele and the homozygous TT genotype of the polymorphic region C3872T were more often detected among healthy individuals. For polymorphism С1444Т it was established that in patients with IHD allele T and genotype TT were more frequent and associated with an increase in the risk of IHD by 1.5 times. We have not identified the relationship between the presence of osteoporosis and the studied polymorphisms of CRP. We studied the distribution of alleles and genotypes depending on the localization of fractures. It was established that C1444T polymorphism is associated with fractures of the radial bone, polymorphism С1846Т is associated with an increased risk of vertebral fractures. Conclusions. C3872T and C1444T polymorphisms of the CRP gene are associated with IHD. In carriers of T allele and CT genotype of C1444T polymorphism, the risk of IHD increased 1.5 times. We did not find any differences in the distribution of alleles and genotypes of the studied polymorphisms when comparing women who have a combination of IHD and osteoporosis with women with IHD. The risk of development of fractures of the radial bone is associated with polymorphism C1444T. For women with CC genotype, the risk is increased by 1.5 times. The risk of vertebral fractures is associated with polymorphism C1846T. The carriers of CT genotype risk increased by 4.5 times.
About the Authors
S. Yu. Tsarenok
Chita State Medical Academy
Russian Federation
Russian Federation
V. V. Gorbunov
Chita State Medical Academy
Russian Federation
Russian Federation
A. A. Dutova
Chita State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Tsarenok S.Yu., Gorbunov V.V., Dutova A.A. The frequency of alleles and genotypes of polymorphism of C-reactive protein gene in women with ischemic heart disease and postmenopausal osteoporosis. Pacific Medical Journal. 2017;(4):65-68. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2017.4.65-68
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