Preview

Pacific Medical Journal

Advanced search

CYTOTOXICITY PHENOMENON AND MECHANISMS OF NEW CORTEX LESIONS WHEN IN HYPOXIA AND ISCHEMIA

Abstract

The paper represents a literature review devoted to the mechanisms of neurons death in the area of ischemia. The generation of both free radicals and peroxinitrites intensifies when there is a restoration of blood supply through the nidus of ischemic lesion and steadily results in necrosis and apoptosis of cortical neurons. Protective mechanisms include glutamate utilization with neuroglial cells, induction of neuronal-form nitrooxidesynthase, superoxide dismutase, neurotrophins and antiapoptotic enzymes. At separate neurons and synapses level, the aforementioned mechanisms are realized by way of local regulation of hemodynamics, which is mediated by neurovasal messengers and neurotransmitters. The balance of neurotoxic and cytoprotective actions determines selective resistance of separate neuron chemotypes to hypoxia and oxidizing stress that in prospects can serve as a basis for elaborating the directional pharmacological correction of the preceding abnormalities.

About the Author

A. G. Matveev
Vladivostok State Medical University
Russian Federation


References

1. Башкатова В.Г., Раевский К.С.// Биохимия. — 1998. - Т. 63, вып. 7. - С. 1020-1028.

2. Завалишин И.А., Захарова М.Н.//Ж. невропатологии и психиатрии им. С.С. Корсакова. — 1996. — №2.-С. 111-114.

3. Королева С.В., Ашмарин И.П.//Успехи физиол. наук. - 2000. - Т. 31, № 1. - С. 31-46.

4. Мотавкин П.А., Пиголкин Ю.В., Каминский Ю.В. Гистофизиология кровообращения в спинном мозге. - М.: Наука, 1994.

5. Реутов В.П.//Известия Академии медицинских наук. - 2000. - С. 35-41.

6. Раевский К.С.//Бюлл. экспер. биол. и мед. — 1997. — Т. 123, № 5. - С. 484-490.

7. Телушкин П.К., Ноздрачев А.Д.// Успехи физиол. наук. - 1999. - Т. 30, № 4. - С. 14-27.

8. Bennett M.R., Balcar V.J.//Neurochem. Int. - 1999. - Vol. 35. - P. 269-280.

9. Bidmon H.-J., Emde B., Kowalski T. et al.//J. Chem. Neuroanat. - 2001. -Vol. 22. - P. 167-184.

10. Brorson J.R., Schumacker P.T., Zhang H.// J. Neurosci. - 1999. - Vol. 19. -P. 147-158.

11. Chan P.H.//J. Cereb. Blood Flow Metab. - 2001. - Vol. 21.-P. 2-14.

12. Chen Y., Swanson R.A.//J. Cereb. Blood Flow Metab. - 2003. - Vol. 23. -P. 137-149.

13. Colasanti M., Suzuki H.// Trends Pharmacol. Sci. — 2000. - Vol. 21. - P. 249-252.

14. Dawson V.L.// Clin. Exp. Pharmacol. Physiol. — 1995. - Vol. 22. - P. 305-308.

15. De la Torre J.C., Stefano G.B.// Brain Res. Rev. - 2000. - Vol. 34. - P. 119-136.

16. Del Zoppo G.J., Mabuchi T.// J. Cereb. Blood Flow Metab. - 2003. - Vol. 23. - P. 879-894.

17. Eliasson M.J.L., Huang Z., Ferrante R.J. et al.// J. Neurosci. - 1999. - Vol. 19. - P. 5910-5918.

18. Estevez A.G., Spear N., Manuel S.M. et al.//J. Neurosci. - 1998. - Vol. 18. - P. 923-931.

19. Estrada C., DeFelipe J.// Cereb. Cortex. - 1998. - Vol. 8. - P. 193-203.

20. Fergus A., Lee K.S.// J. Cereb. Blood Flow Metab. - 1997. - Vol. 17.-P. 992-1003.

21. Friebe A., Schultz G., Koesling D.// Biochem. J. — 1998. - Vol. 335. - P. 527-531.

22. Gonzalez-Zulueta M., Ensz L.M., Mukhina G. et al.// J. Neurosci. - 1998. -Vol. 18. - P. 2040-2055.

23. Hanbury R., Ling Z.D., Wuu J. et al.//J. Comp. Neurol. - 2003. - Vol. 461. - P. 307-316.

24. Hata R., Maeda K., Hermann D. et al.// Cereb. Blood Flow Metab. - 2000. - Vol. 20. - P. 937-946.

25. Hayashi T. Chemical physiology of excitation in muscle and nerve. — Tokyo: Nakayama-Shoten, 1956.

26. Hicks T.P., Conti F.// Can. J. Physiol. Pharmacol. - 1996. - Vol. 74. - P. 341-361.

27. Iadecola C., Li J., Xu S., Yang G.// J. Neurophysiol. — 1996. - Vol. 75. - P. 940-950.

28. Johansson B.B., Belichenko P.V.//J. Cereb. Blood Flow Metab. - 2002. -Vol. 22. - P. 89-96.

29. Keller J.N., Kindy M.S., Holtsberg F.W. et al.//J. Neurosci. - 1998. - Vol. 18. - P. 687-697.

30. Pieper A.A., Blackshaw S., Clements E.E. et al.// Proc. Natl. Acad. Sci. USA. - 2000. - Vol. 97. - P. 1845-1850.


Review

For citations:


Matveev A.G. CYTOTOXICITY PHENOMENON AND MECHANISMS OF NEW CORTEX LESIONS WHEN IN HYPOXIA AND ISCHEMIA. Pacific Medical Journal. 2004;(2):18-23. (In Russ.)

Views: 217


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1609-1175 (Print)