APPLICATION OF ORGANIC NITRATES DURING TREATMENT OF CHRONIC CORONARY HEART DISEASE FROM THE POSITION OF PHARMACOECONOMIC EFFECTIVENESS

Abstract

The long-term course of the cardiovascular diseases results in considerable financial losses of the state and the individual. The purpose of this work was to carry out the pharmacoeconom-ic analysis based on the cost minimization methods and the index «cost/effectiveness» of various groups and forms of organic nitrates, which was going to be made retrospectively, by the results of open controlled clinical trials. 295 patients suffering from stable angina pectoris of different functional classes had participated in the investigations. The analysis of the findings showed that derivatives of isos-orbide-5-mononitrite of ordinary release form had been the most cost-effective. The least costs per effectiveness unit had had prolonged nitrates: kardiket 40 retard and efox long. Thus, prolonged nitrates application under coronary heart disease is more rational and economically sound.