INDICES OF CELL-MEDIATED IMMUNITY AT PATIENTS SUFFERING FROM UROGENITAL UREAPLASMIC INFECTION

Abstract

The article describes the features of cellular indices of immune state under different forms of urogenital ureaplasmic infection. As to monoureaplasmosis there was a decrease in abundance of CD3-lymphocytes and increase in level of B-lympho-cytes (CD22). Reduction of index of the ratio HLA-DR/CD95 was the evidence of the apoptosis predominance over the processes of cellular proliferation and differentiation. Under mixed infection by U. urealyticum and Ch. trachomatis there was an immunodeficiency state of combined type characterized by decrease in CD3- and CD4-lymphocytes and CD56-(killer) cells, as well as by disturbances in the ratio of immunoregulation cells (CD4/CD8), and enhancement of Fas- mediated apoptosis, that was the evidence of apparent imbalance of regulatory mechanisms. Predominance of the activation processes with considerable increase of B-lymphocytes, as well as markers of early and late cell activation were registered when U. urealyticum was associated with C. albicans against the background of decrease in abundance of CD3- and CD4-lymphocytes.