BIOCHEMICAL MARKERS OF BONE TISSUE METABOLISM AND THEIR CLINICAL VALUE UNDER CHRONIC OBSTRUCTIVE LUNGS DISEASE

Abstract

So as to research the features of bone metabolism under all main variants of the chronic obstructive lungs diseases the authors examined 95 patients (30 women and 65 men) and diagnosed diminution of bone density at 78% of patients. The rate of osteoporosis was higher when there was lungs emphysema than under chronic obstructive bronchitis, and the degree of the decrease in bone density depended on the intensity of the bronchial obstruction. At 73,6% of cases the authors detected the increase of bone résorption under relatively stable bone formation that became apparent by increasing in CrossLaps concentration. Close correlation ratios between proinflammatory cytokines, bone density and bone metabolism markers define the important role of cytokine-mediated mechanisms in patho-genesis of pulmonary osteopenia.