NITROXIDERGICAL MECHANISMS OF PAIN FORMATION
Abstract
The survey presents the analysis of segmental and su-praspinal nitroxidergical mechanisms of pain sensitivity regulation. In systemic integrative pain reaction the nitric oxide is a participant of all its components being connecting-link between afferent painful impulsation and adaptative change of central nervous system. In the nitric oxide synthesis system the painful impact is accompanied by considerable changes, their intensity and directedness have specific profile in different brain structures and depend on pain parameters. Enhancing the tonus of upward nociceptive systems, the nitric oxide at the same time controls endogenous antialgesic mechanisms and can have an influence upon the effectiveness of analgesic effect of opiates. Thereupon nitroxidergical brain system can be regarded as potential target for complex drug pain therapy.
About the Authors
P. A. Motavkin
Vladivostok State Medical University
Russian Federation
Russian Federation
I. V. Dyuyzen
Sea Biology Institute of Far-Eastern Branch Office of Russian Academy of Science
Russian Federation
Vladivostok
Russian Federation
Vladivostok
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Review
For citations:
Motavkin P.A., Dyuyzen I.V. NITROXIDERGICAL MECHANISMS OF PAIN FORMATION. Pacific Medical Journal. 2003;(2):11-16. (In Russ.)
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