CLINICOPATHOGENETIC FEATURES OF ISCHEMIC HEART DISEASE OF THE PATIENTS OF DIFFERENT

Abstract

These researchers showed the analysis of 1821 medical histories of the patients of specialized infarction department so as to assess the clinical course of the disease. They examined 50 patients, both men and women, at the age of 37-79 years with acute coronary syndrome, and 62 patients at the age of 25-50; 45 persons suffered from different forms of ischémie heart disease; among them there were 17 patients with risk factors for ischémie heart disease development. The examination included the detection of NO metabolite content, the tumor necrosis factor and C-reactive protein and sex hormones in blood serum. The young patients had the infarct that developed suddenly and proceeded with anxious and phobic reaction whereas the patients in years had depressive disorders. It was shown the reliable change of the sex hormones level of the men and women aged till 50 with risk factors and of patients with ischémie heart disease. The NO-producing system of vessel endotheli-um was reducing especially as regards the persons of the elderly age. The examined immune activation markers were bound up with coronary syndrome form and with the patients' age.