Prediction of chickenpox in adults
https://doi.org/10.34215/1609-1175-2023-2-48-53
Abstract
Aim. To evaluate the potential for detecting of gene allelic polymorphism for chickenpox in adults.
Materials and methods. The examination involved 201 conscripted soldiers of Caucasian race, aged between 18 and 24, who were born in and served in Zabaykalsky Krai. Determination of gene polymorphism was carried out via polymerase chain reaction. Genomic DNA was extracted from whole blood leukocytes using DNA-Express reagent. IBM SPSS Statistics 25.0 (International Business Machines Corporation, License No. Z125-3301-14, USA) was used for statistical processing of the results.
Results. IL-10(G1082A) obtains the highest predictive value for chickenpox, while TLR9(T1237C) – the lowest. More commonly, chickenpox affects adults with IL-10(C819T), IL-10(G1082A) and TLR9(A2848G). TLR9(T1237C) is insignificant for chickenpox. TT and TC IL-10(G1082A), GA and AA TLR9(A2848G), AG and GG IL-10(C819T) are activators of chickenpox. AA IL-10(G1082A), CC IL-10(C819T), AA TLR9(A2848G) are chickenpox protectors. Android app was created for prognosis and early diagnosis of chickenpox in adults.
Conclusion. Genes GA, AA IL-10(G1082A, and TT, CT IL-10(C819T), as well as AG, GG TLR9(A2848G) predispose to chickenpox, and gene AA TLR9(A2848G) reduces the probability of developing the disease. Considering that, the main prognostic markers for chickenpox in adults are polymorphisms of genes IL-10(G1082A), TLR9(A2848G), IL-10(C819T), the developed diagnostic model allows for the prediction and early diagnosis of the disease.
About the Authors
T. A. Krivolutskaya
Branch No.2 of the 1477 Naval Clinical Hospital of the Ministry of Defense of the Russian Federation; Chita State Medical Academy
Russian Federation
Russian Federation
Tatiana A. Krivolutskaya - Infectious diseases doctor of the Branch No. 2 1477 of the Naval Clinical Hospital; correspondence postgraduate student of the Department of Infectious Diseases and Epidemiology of the Chita SMA.
Ammonal Pad str., Petropavlovsk-Kamchatsky, 683015; tel.: +7 (914) 360-81-88
A. B. Makarov
Military Medical Academy named after S.M. Kirov
Russian Federation
Russian Federation
St. Petersburg
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Review
For citations:
Krivolutskaya T.A., Makarov A.B. Prediction of chickenpox in adults. Pacific Medical Journal. 2023;(2):48-53. (In Russ.) https://doi.org/10.34215/1609-1175-2023-2-48-53
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