Development of a prognostic algorithm for risk of retinal vein occlusions under geomagnetic perturbations

Aim. To develop a screening and prognostic algorithm for the risk of retinal vein occlusion in geomagnetic disturbances in patients with arterial hypertension.

Materials and methods. In total, 1512 patients with arterial hypertension of 1–4 stages were included in the study. Within three years, 391 patients developed retinal venous occlusions. A comparative study of the parameters of systemic and regional hemodynamics, microcirculatory parameters of the eyes of these patients was carried out both in a magnetically calm environment and during geomagnetic disturbances. To simulate the response of microcirculatory bed to stress, a functional pharmacological instillation test was performed with a 10% irifrin solution. To assess the geomagnetic situation, the К_р-index was used, which objectively characterizes fluctuations of the Earth’s magnetic field over a three-hour time interval. The International Classification of К_р values was used.

Results. For statistical analysis, 78 studied signs of systemic, regional hemodynamics and microcirculation were selected. The prognostic significance of 30 studied signs was revealed. A training group (1434 people) and an examination group (78 people) were formed. Based on the training group, a predictive algorithm was formed. A number of regularities were established that made it possible to create a system for identifying the risk of retinal vein thrombosis during geomagnetic disturbances in patients with hypertension. To determine the risk of retinal vein occlusion, a coefficient was developed. The sensitivity of algorithm was 89%, the specificity was 94%.

Conclusion. A prognostic algorithm for determining the risk of occlusive lesions of the retinal veins during geomagnetic disturbances for patients with arterial hypertension with high sensitivity and specificity (88% и 90%, respectively) was developed.

1. Tankovskii VE. Retinal vein thrombosis. Moscow: Meditsina, 2000. 263 p. (In Russ.).

2. Evans K, Wishart PK, McGalliard JN. Neovascular complications after central retinal vein occlusion. Eye. 1993;7(4):520–4. doi: 10.1038/eye.1993.113

3. Quinlan PM, Elman MJ, Bhatt AK, Mardesich P, Enger C. The natural course of central retinal vein occlusion. Am J Ophthalmol. 1990;110(2):118–23. doi: 10.1016/s0002-9394(14)76979-x

4. Hayreh SS, Zimmerman B, McCarthy MJ, Podhajsky P. Systemic diseases associated with various types of retinal vein occlusion. Am J Ophthalmol. 2001;131(1):61–77. doi: 10.1016/s0002-9394(00)00709-1

5. Marchenko TK. Influence of heliogeophysical and meteorological factors on the human body. Human Physiology. 1998;(2):122–7 (In Russ.).

6. Pomytkina NV, Egorov VV, Sorokin EL. The influence of geomagnetic disturbances to the state of eye microcirculation at patients with retinal vein occlusion. Ophtalmosurgery. 2010;(5):42–6 (In Russ.).

7. Egorov VV, Egorova AV, Smolyakova GP, Sorokin EL. Clinical and morphometric macular changes in patients with diabetes mellitus after cataract phacoemulsification. The Russian Annals of Ophthalmology. 2008;124(4):22–5 (In Russ.).

8. Pomytkina NV, Egorov VV, Sorokin EL. The examination of adaptive possibilities of eye microcirculation system in patients with retinal vein occlusion in case of geomagnetic disturbances. Bulletin of the Orenburg State University. 2010;(12):194–8 (In Russ.).

9. Pomytkina NV, Sorokin EL. Geomagnetic activity influence on the eye microcirculation at the retinal vein occlusion. Bulletin of the Novosibirsk State University. Series: Biology, Clinical Medicine. 2012;10(5):130–4 (In Russ.).

10. Pomytkina NV, Egorov VV, Sorokin EL. Effect of geomagnetic disturbances on the occurrence of retinal vein thrombosis in patients with essential hypertension. Khabarovsk, 2015. 107 p. (In Russ.).

11. Pomytkina NV, Sorokin EL, Egorov VV. Research of microcirculation of an eye in patients with an idiopathic hypertensia for revealing of acute vascular accidents risk in an eye. Bulletin of the East Siberian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences. 2011;(6):71–3 (In Russ.).

12. Kolenko OV, Sorokin EL, Egorov VV. Studying of patterns of dynamics of macular retina micromorphometric indicators in pregnant women at pathological pregnancy in interrelation with gestosis severity. Kuban Scientific Medical Bulletin. 2013;137;(2):48–52 (In Russ.).