Assessment of interleukin-17 system in children with allergic bronchial asthma
https://doi.org/10.17238/PmJ1609-1175.2018.4.37-40
Abstract
Objective. The study objective is to assess Th17 subpopulation of T-lymphocytes and to analyze the features of serum interleukins 17А and 17F (IL-17A, IL-17F) in children with allergic bronchial asthma. Methods. The study includes 60 children with allergic bronchial asthma and 30 healthy children. Withdrawal criteria from the study was virus-induced phenotype, severe course of asthma, administration of immunocorrecting drugs. The material for the study is venous blood. Cells were assessed with on a flow cytofluorimeter MACSQuant (Miltenyi Biotec GmbH, Germany). Immunoenzyme method was used to determine the content of IL-17A, IL-17F with eBiociens reagents (Bender Medsystems GmbH, Austria), IgE with reagents from the company Alkor Bio (St. Petersburg). Results. In the serum of children with asthma, a high level of IL-17A was detected, a moderate direct correlation of its concentration with the number of neutrophils in the peripheral blood and eosinophils in the nasal secretion was determined. Conclusions. Variability of the functional and quantitative characteristics of the interleukin-17 system was determined depending on the prevalence of allergic inflammation, the significance of imbalance in the interleukin-17 system, and the influence of Th17 lymphocytes on various aspects of inflammation and hyperreactivity of the bronchi associated with T-helpers, types 1 and 2.
About the Authors
E. V. Prosekova
Pacific State Medical University
Russian Federation
Russian Federation
A. I. Turyanskaya
Pacific State Medical University
Russian Federation
Russian Federation
V. A. Sabynych
Pacific State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Prosekova E.V., Turyanskaya A.I., Sabynych V.A. Assessment of interleukin-17 system in children with allergic bronchial asthma. Pacific Medical Journal. 2018;(4):37-40. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2018.4.37-40
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