Metabolically-oriented effect of fucoidan from Sargassum feldmannii brown algae on the mda-mb-231 human breast cancer cells
https://doi.org/10.34215/1609-1175-2024-4-69-75
Abstract
Objective. To study the effect of fucoidan from brown algae S. feldmannii (SfF2) on the metabolism of MDA-MB-231 breast cancer cells.
Materials and methods. The bioenergetic potential of MDA-MB-231 cells was assessed under the influence of various factors (insulin, epidermal growth factor, phorbol ester, and X-rays) stimulating tumor progression. The metabolically oriented effect of fucoidan SfF2 (200 µg/ml) on the colony formation process of MDA-MB-231 human breast cancer cells was determined using the soft agar method under normal conditions and under the influence of various carcinogenic factors.
Results. Fucoidan from brown algae S. feldmannii was found to reduce the number of colonies of MDA-MB-231 cells induced by insulin, epidermal growth factor (EGF), and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) by more than 50 % compared to control cells.
Conclusion. The use of fucoidan as an adjunct to standard therapy appears to be a promising strategy for enhancing the efficacy of anticancer treatment.
Supporting agencies: The work was carried out with the financial support of the Russian Science Foundation grant No. 21-14-00321
About the Authors
O. S. Malyarenko
G.B. Elyakov Pacific Institute of Bioorganic Chemistry of Far Eastern Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Vladivostok
A. O. Zueva
G.B. Elyakov Pacific Institute of Bioorganic Chemistry of Far Eastern Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Vladivostok
R. V. Usoltseva
G.B. Elyakov Pacific Institute of Bioorganic Chemistry of Far Eastern Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Vladivostok
A. S. Silchenko
G.B. Elyakov Pacific Institute of Bioorganic Chemistry of Far Eastern Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Vladivostok
S. P. Ermakova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry of Far Eastern Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Svetlana P. Ermakova, Dr. Sci. (Med.), Head of the Laboratory
Laboratory of Enzyme Chemistry
690022; 159, Prospect 100-lyet Vladivostoku; Vladivostok
phone: (423) 231-07-05
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Review
For citations:
Malyarenko O.S., Zueva A.O., Usoltseva R.V., Silchenko A.S., Ermakova S.P. Metabolically-oriented effect of fucoidan from Sargassum feldmannii brown algae on the mda-mb-231 human breast cancer cells. Pacific Medical Journal. 2024;(4):69-75. (In Russ.) https://doi.org/10.34215/1609-1175-2024-4-69-75
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