Changes in the level of pro-inflammatory cytokines in women with diseases of the cervix uterus associated human papillomavirus infection

Abstract

Objective. The content of interferon-γ (IFN-y) and interleukins (IL) 13 and 17 in the serum of women with human papillomavirus infection was examined. Methods. 38 patients with chronic cervicitis associated with human papillomavirus infection (average age 26.2 years), including 18 - with pointed anogenital warts were observed. The control group - 10 healthy female volunteers. Cytokine levels were determined using specific reagents from R&D Diagnostics Inc. (USA) by the sandwich method of enzyme-linked immunosorbent assay. Results. The levels of IFN-γ and IL-17 in the serum increased, however, no significant differences between the groups examined in various clinical variants of human papillomavirus infection were found. The level of IL-13 in women with anogenital warts was twice as high as in patients without anogenital warts. Conclusions. The increase in the content of all cytokines presented in the study in the serum testified to the activation of the immune system. The high content of IL-13 in human papillomavirus infection can serve as a marker of a persistent inflammatory reaction that accompanies the development of warts.