The status of the matrix metalloproteinase system in patients with community-acquired pneumonia
https://doi.org/10.34215/1609-1175-2026-2-41-44
Abstract
Objective: To assess the status of the matrix metalloproteinase (MMP) system in patients with severe community-acquired pneumonia (CAP) based on serum levels of MMP-2, MMP-7, and the MMP-9/TIMP-1 and MMP-9/TIMP-2 complexes, as well as to monitor these levels over time.
Materials and methods. An open-label observational comparative study was conducted. The main cohort included 55 patients with severe CAP. The control group consisted of ten normally healthy volunteers. Venous blood samples were collected on days 1, 3, 6, 9, and 12 (in the control group, a single sample was collected). Marker concentrations were determined using the ELISA method. Statistical analysis was performed using SPSS 25.0.
Results. Dynamic monitoring revealed no clear, single-directional dynamics for the MMP-2 and MMP-9/TIMP complexes. However, MMP-7 levels decreased by day 3 and subsequently increased. This may correspond to a shift between the inflammatory and reparative phases during the fluctuating progression of severe CAP.
Conclusion. Serum MMP-7 levels are a promising marker of CAP severity; their dynamics correlate with early protease-dependent remodeling and worsening lung barrier dysfunction.
About the Authors
P. A. Knyazenko
Pacific State Medical University; Vladivostok Clinical Hospital No. 1
Russian Federation
Russian Federation
Vladivostok
E. V. Markelova
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
A. V. Kostyushko
Pacific State Medical University
Russian Federation
Russian Federation
Anna V. Kostyushko - Cand. Sci. (Med.), Associate Professor, Associate Professor of the Department of Normal and Pathological Physiology.
2 Ostryakova ave., Vladivostok, 690002
E. V. Bakhtina
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
Ya. A. Khlystun
Pacific State Medical University
Russian Federation
Russian Federation
Vladivostok
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Review
For citations:
Knyazenko P.A., Markelova E.V., Kostyushko A.V., Bakhtina E.V., Khlystun Ya.A. The status of the matrix metalloproteinase system in patients with community-acquired pneumonia. Pacific Medical Journal. 2026;(2):41-44. (In Russ.) https://doi.org/10.34215/1609-1175-2026-2-41-44
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