ORGANOMETRIC PARAMETERS OF THYMUS OF WHITE RATS EXPOSED TO INHALATION EXPOSURE TO FORMALDEHYDE AND THEIR PREDICTION USING SINGLE-FACTOR LINEAR REGRESSION ANALYSIS
https://doi.org/10.17238/PmJ1609-1175.2019.3.37-41
Abstract
Objective: to conduct organometry of thymus gland of white rats which were in the conditions of inhalation exposure to formaldehyde, and to build a regression model of the relationship between the length and width of the organ.
Methods: The study was done on 72 white male rats with initial body weight 130–150 g, aged 3 months old. Exposure to formaldehyde at a concentration of 2.766 mg /m3 was carried out daily for 60 minutes from 10 to 90 days in different observation groups. We measured the body weight of animals, the absolute and relative weight and size of the thymus gland. A regression analysis of the dependence of the length of the body on its width was carried out.
Results: The average absolute mass of the thymus of rats exposed to formaldehyde for 20 days was 224.17 mg, which was 14.9 % lower than the control values. The created model of dependence of the thymus length on its width is described by the formula Y=2.7+1.25×X, where Y is the length and X is the width.
Conclusions: As a result of the influence of formaldehyde, a decrease in the absolute mass of the thymus is observed. However, its relative mass does not differ from the indicators of the corresponding norm. Formaldehyde exposure to rats leads to reduction of the size of the thymus gland. The created model of dependence of the thymus length on its width allows predicting the values of the dependent variable.
About the Author
I. Yu. Vash
St Luke Lugansk State Medical University
Russian Federation
1g, 50 let Oborony Luganska Sq. 91045 Lugansk
Russian Federation
1g, 50 let Oborony Luganska Sq. 91045 Lugansk
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Review
For citations:
Vash I.Yu. ORGANOMETRIC PARAMETERS OF THYMUS OF WHITE RATS EXPOSED TO INHALATION EXPOSURE TO FORMALDEHYDE AND THEIR PREDICTION USING SINGLE-FACTOR LINEAR REGRESSION ANALYSIS. Pacific Medical Journal. 2019;(3):37-41. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2019.3.37-41
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