EXPERIENCE OF CLINICAL USING OF PHARMACOLOGICAL NEUROPROTECTION AFTER ENDOVITREAL SURGERY OF RHEUMATOGENIC RETINAL DETACHMENT
https://doi.org/10.17238/PmJ1609-1175.2019.2.19-21
Abstract
Objective: to assess the effectiveness of ‹Cytoflavinum’ in patients with low visual prognosis after endovitreal surgery of rheumatogenic retinal detachment (RRD) with anatomical attachment.
Methods: 28 people (28 eyes) aged from 16 to 54 y.o. were observed with primary RRD covering macular area. We performed three-port vitrectomy with silicon oil tamponade of vitreous cavity and its removal. Patients were divided into two groups: main group – 16 people having taken ‘Cytoflavinum’ along with standard therapy, and control group – 12 people (only standard therapy).
Results: Most significant positive changes of value growth amplitude and microcirculation efficiency index were noted in patients of the main group in six months after surgery; most significant positive changes were noted using optical coherent tomography-angiography compared to patients of the control group.
Conclusions: Using neuroprotector ‘Cytoflavinum’ in therapy after endovitreal surgery of RRD significantly increases the quality of functional surgery outcome due to activation of chorioretinal blood flow.
About the Authors
V. V. EgorovRussian Federation
211 Tikhookeanskaya St. Khabarovsk 680033 Russian Federation
9 Krasnodarskaya St. Khabarovsk 680000 Russian Federation
A. V. Egorov
Russian Federation
211 Tikhookeanskaya St. Khabarovsk 680033 Russian Federation
G. P. Smoliakova
Russian Federation
211 Tikhookeanskaya St. Khabarovsk 680033 Russian Federation
9 Krasnodarskaya St. Khabarovsk 680000 Russian Federation
References
1. Zavgorodnyaya N.G. The hemodynamic background in patients with rhegmatogenous retinal detachment // Zaporozhye Medical Journal. 2014. No. 5. P. 66–69.
2. Egorov V.V., Egorov A.V., Smoliakova G.P. Clinical analysis of visual recovery in patients after successfully endovitreal surgical treatment of complicated rhegmatogenous retinal detachment // Modern Technologies in Ophthalmology. 2016. No. 1. P. 71–75.
3. Zayka V.A. Patho- and sanogenetic mechanisms determining the outcome of surgical treatment of retinal detachment: Dissertation abstracts. Irkutsk, 2015. 24 p.
4. Egorova E.N. The use of ozone therapy in rehabilitation period in patients after surgery of rheumatogenic retinal detachment: Dissertation abstracts. Moscow, 2007. 25 p.
5. Ivanov S.V., Mashkovtsev V.M., Cherygova E.G. The first experience of using retinalamin in complex treatment of patients with rheumatogenic retinal detachment // Modern technologies in treatment of vitreoretinal pathology 2010: Abstracts of scientific and practical. conf. Moskow, 2010. P. 51–52.
6. Zavgorodnyaya N.G. The hemodynamic background in patients with rhegmatogenous retinal detachment // Zaporozhye Medical Journal. 2014. No. 5. P. 66–69.
7. Karazhaeva M.I., Saksonova E.O., Klebanov G.I. [et al.]. Flavonoid antioxidants in the complex treatment of patients with dystrophic retinal detachment // RMJ. Clinical ophthalmology. 2004. Vol. 5, No. 1. P. 41–43.
8. Zayka V.A. Patho- and sanogenetic mechanisms determining the outcome of surgical treatment of retinal detachment: Dissertation abstracts. Irkutsk, 2015. 24 p.
9. Krasnogorskaya V.N., Gusev A.N., Sorokina E.V. The use of Cytoflavin in complex treatment of primary open-angle glaucoma // Pacific Medical Journal. 2012. No. 3. P. 19–20.
10. Ivanov S.V., Mashkovtsev V.M., Cherygova E.G. The first experience of using retinalamin in complex treatment of patients with rheumatogenic retinal detachment // Modern technologies in treatment of vitreoretinal pathology 2010: Abstracts of scientific and practical. conf. Moskow, 2010. P. 51–52.
11. Libman E.S., Shakhova E.V. Blindness and disability due to pathology of the organ of vision in Russia // Annals of Ophthalmology. 2006. Vol. 122, No. 1. P. 35–37.
12. Karazhaeva M.I., Saksonova E.O., Klebanov G.I. [et al.]. Flavonoid antioxidants in the complex treatment of patients with dystrophic retinal detachment // RMJ. Clinical ophthalmology. 2004. Vol. 5, No. 1. P. 41–43.
13. Mashchenko N.V., Khudyakov A.Yu., Lebedev Ya.B. [et al.]. The comparative analysis of surgical treatment of primary rheumatogenic retinal detachment by methods of episkleral and vitreal surgery // Modern Technologies in Ophthalmology. 2014. No. 1. P. 77–78.
14. Krasnogorskaya V.N., Gusev A.N., Sorokina E.V. The use of Cytoflavin in complex treatment of primary open-angle glaucoma // Pacific Medical Journal. 2012. No. 3. P. 19–20.
15. Suslina Z.A., Tanashyan M.M., Smirnova I.N. [et al.]. Antioxidant and neurotrophic effects of Cytoflavin in chronic cerebrovascular diseases // Vestnik SPbSMA. 2002. No. 3. P. 110–114.
16. Libman E.S., Shakhova E.V. Blindness and disability due to pathology of the organ of vision in Russia // Annals of Ophthalmology. 2006. Vol. 122, No. 1. P. 35–37.
17. Tahchidi Kh.P., Kazaikin V.N., Rapoport A.A. [et al.]. Prediction of the results of treatment of retinal detachment using silicone tamponade based on pattern recognition methods // Bulletin of the Russian Academy of Medical Sciences. 2007. No. 8. P. 31–36.
18. Mashchenko N.V., Khudyakov A.Yu., Lebedev Ya.B. [et al.]. The comparative analysis of surgical treatment of primary rheumatogenic retinal detachment by methods of episkleral and vitreal surgery // Modern Technologies in Ophthalmology. 2014. No. 1. P. 77–78.
19. Uni Burauy Metabolic therapy in complex treatment of patients with partial optic nerve atrophy secondary origin: Dissertation abstracts. St Petersburg, 2005. 24 p.
20. Suslina Z.A., Tanashyan M.M., Smirnova I.N. [et al.]. Antioxidant and neurotrophic effects of Cytoflavin in chronic cerebrovascular diseases // Vestnik SPbSMA. 2002. No. 3. P. 110–114.
21. Colucciello M., Rasier R. Rhegmatogenous retinal detachment // Phys. Sportsmed. 2009. Vol. 37, No. 2. P. 59–65.
22. Tahchidi Kh.P., Kazaikin V.N., Rapoport A.A. [et al.]. Prediction of the results of treatment of retinal detachment using silicone tamponade based on pattern recognition methods // Bulletin of the Russian Academy of Medical Sciences. 2007. No. 8. P. 31–36.
23. Coppe A.M., Lapucci G. Posterior vitreous detachment and retinal detachment following cataract extraction // Curr. Opin. Ophthalmol. 2008. Vol. 19, No. 3. P. 239–242.
24. Uni Burauy Metabolic therapy in complex treatment of patients with partial optic nerve atrophy secondary origin: Dissertation abstracts. St Petersburg, 2005. 24 p.
25. Mitry D., Charteris D.G., Yorston D. [et al.]. Rhegmatogenous retinal detachment in Scotland: research in design and methodology // BMC Ophtalmol. 2009. doi: 10.1186/1471-2415-9-2.
26. Colucciello M., Rasier R. Rhegmatogenous retinal detachment // Phys. Sportsmed. 2009. Vol. 37, No. 2. P. 59–65.
27. Coppe A.M., Lapucci G. Posterior vitreous detachment and retinal detachment following cataract extraction // Curr. Opin. Ophthalmol. 2008. Vol. 19, No. 3. P. 239–242.
28. Mitry D., Charteris D.G., Yorston D. [et al.]. Rhegmatogenous retinal detachment in Scotland: research in design and methodology // BMC Ophtalmol. 2009. doi: 10.1186/1471-2415-9-2.
Review
For citations:
Egorov V.V., Egorov A.V., Smoliakova G.P. EXPERIENCE OF CLINICAL USING OF PHARMACOLOGICAL NEUROPROTECTION AFTER ENDOVITREAL SURGERY OF RHEUMATOGENIC RETINAL DETACHMENT. Pacific Medical Journal. 2019;(2):19-21. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2019.2.19-21