OPTIMIZATION TECHNIQUES TO TREAT INJURIES OF DIFFERENT GENESIS
https://doi.org/10.17238/PmJ1609-1175.2019.2.80-83
Abstract
Objective: to assess results of treatment of injuries of different genesis with the use of antioxidants and hyperbaric oxygen therapy (HOT).
Methods: We analyzed the results of treatment of 80 patients aged 20–60 y.o. with injuries of different genesis and localization divided into main and control groups (40 patients each). Along with traditional treatment the main group received antioxidant therapy (oral intake of biologically active supplement “Lavitol-V” and applied topically – dihydroquercetin powder for 21 days). Simultaneously patients with burns of the1-2 stages received 8–10 sessions of HOT, and patients with burns of the 3 stage and with persistent wounds received 3–4 sessions of HOT with consecutive autodermoplasty and continued to receive HOT with antioxidant therapy since the first day of post-surgery period.
Results: Positive wound process was observed in patients of the main group: less pain severity, early epithelization and wounds cicatrization, decrease of proinflammatory cytokines level and lipid peroxidation rate in blood serum. Due to activation of repair process we were able to reduce the time of self-epithelization in burns of the 1–2 stages, and the time of preoperative preparation for deferred autodermoplasty in burns of the 3 stage and in persistent wounds, and to improve the results of graft retention compared to a traditional treatment.
Conclusions: Antioxidant therapy and HOT influence pathogenetically on wound process, and suggested way of treatment combines positive effects of both methods.
About the Authors
O. S. Olifirova
Amur State Medical Academy
Russian Federation
95 Gorkogo St. Blagoveschensk 675000 Russian Federation
Russian Federation
95 Gorkogo St. Blagoveschensk 675000 Russian Federation
A. A. Kozka
Amur State Medical Academy
Russian Federation
95 Gorkogo St. Blagoveschensk 675000 Russian Federation
Russian Federation
95 Gorkogo St. Blagoveschensk 675000 Russian Federation
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Review
For citations:
Olifirova O.S., Kozka A.A. OPTIMIZATION TECHNIQUES TO TREAT INJURIES OF DIFFERENT GENESIS. Pacific Medical Journal. 2019;(2):80-83. (In Russ.) https://doi.org/10.17238/PmJ1609-1175.2019.2.80-83
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