Molecular and genetic mechanisms of endothelial dysfunction in children with allergic enteropathy
https://doi.org/10.34215/1609-1175-2019-4-32-35
Abstract
Objective. The objective is to analyze molecular and genetic mechanisms of endothelial dysfunction development in children with allergic enteropathy.
Methods: We have studied the polymorphisms of endothelial nitric oxide synthase gene and the level of nitric oxide metabolites in coprofiltrates in 43 children aged from 6 months to 3 years with allergic enteropathy.
Results: The endothelial dysfunction in allergic enteropathy is associated with nitric oxide molecule. Carriage of the homozygous allele СС Т786С of the endothelial nitric oxide synthase gene raises the risk of IgE-independent food allergy development by 8.8 times.
Conclusions: The conducted study evidences the active participation of nitric-oxidergic mechanism in allergic inflammation development.
About the Authors
T. A. Shumatova
Pasific State Medical University
Russian Federation
Russian Federation
Tatiana A. Shumatova, MD, PhD, professor, head of the Institute of Pediatrics
2 Ostryakova Ave., Vladivostok, 690002
N. G. Prihodchenko
Pasific State Medical University
Russian Federation
Vladivostok
Russian Federation
Vladivostok
E. S. Zernova
Pasific State Medical University
Russian Federation
Vladivostok
Russian Federation
Vladivostok
References
1. Pampura AN. Food allergy in young children. Pediatrics. 2016;95(3):152–7 (In Russ.).
2. Shumatova TA, Prikhodchenko NG, Zernova ES, Efremova IV, Shishatskaya SN, Ni AN, et al. The gene polymorphism of the folate cycle and endogenous peptides in children with allergy to cow›s milk protein. Russian Journal of Perinatology and Pediatrics. 2016;61(6): 113–8 (In Russ.).
3. Berin MC, Sampson HA. Mucosal immunology of food allergy. Curr Biol. 2013:6(23):389–400.
4. Steele L, Mayer L, Berin MC. Mucosal immunology of tolerance and allergy in the gastrointestinal tract. Immunol Res. 2012; 54(1):75–82.
5. Shumatov TA, Zernova ES, Grigoryan LA, Shishatskaya CH. Antimicrobial peptides and proteins in the diagnosis of malabsorption syndrome in children. Modern Problems of Science and Education. 2015;3 (In Russ.). URL: http://www.scienceeducation.ru/ru/article/view?id=20324 (Accessed: 9 Nov 2016).]
6. Shumatova TA, Prikhodchenko NG, Nee AN, Katenkova EYu, Grigoryan LA, Zernova ES, Shishatskaya SN. Zonulin, TNF-α and nitric oxide in the diagnosis of IgE-dependent and IgE-independent food allergies in children. Pacific Medical Journal. 2017;2:18–20 (In Russ.).
7. Shumatova TA, Katenkova EYu, Zernova ES, Shishatskaya SN, Grigoryan LA, Egorova SV. Features of the metabolism of endogenous peptides in children with gastrointestinal form of food allergy. Questions of Children’s Nutrition. 2016;14(2):13–7 (In Russ.).
8. Cibor D, Domagala-Rodacka R, Rodacki T, Jurczyszyn A, Mach T, Owczarek D. Endothelial dysfunction in inflammatory bowel diseases: pathogenesis, assessment and implications. World J Gastroenterol. 2016;22(3):1067–77.
9. Kochar NI, Chandewal AV, Bakal RL, Kochar PN. Nitric oxide and the gastrointestinal tract. Int J Pharmacol. 2011;7:31–9.
10. Bogdan C. Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol. 2015;36(3):161–78.
11. Scurlock AM, Vickery BP, Hourihane JO, Burks AW. Pediatric food allergy and mucosal tolerance. Mucosal Immunol. 2010; 3(4):345–54.
12. Stepanova EI, Skvarskaia EA. Role of polymorphism NOS gene in the pathogenesis of multifactorial diseases. Lik Sprava. 2014;5–6:47–55.
13. Mattila JT, Thomas AC. Nitric oxide synthase: non-canonical expression patterns. Front Immunol. 2014;9(5):478.
14. Kolesov SA, Zhukova EA, Korkotashvili LV, Fedulova EN, Tutina OA,Tolkacheva NI. Metabolity oksida azota, belok teplovogo shoka 70 i provospalitelnyye tsitokiny u detey s zabolevaniyami kishechnika Mezhdunarodnyy zhurnal prikladnykh i fundamentalnykh issledovaniy. 2014;4:75–8 (In Russ.).
15. Panova IW, Dudnikova IW. Nitric oxide and endothelin-1 in the pathology of the digestive system in children. Questions of modern pediatrics. 2012;11(5):56–62 (In Russ.).
Review
For citations:
Shumatova T.A., Prihodchenko N.G., Zernova E.S. Molecular and genetic mechanisms of endothelial dysfunction in children with allergic enteropathy. Pacific Medical Journal. 2019;(4):32-35. (In Russ.) https://doi.org/10.34215/1609-1175-2019-4-32-35
Views:
596
Email this article 