The connection of disorders of gas and electrolytic composition of venous blood with kidney dysfunction in patients with chronic obstructive pulmonary disease of different exacerbation risk

Abstract

Objective: Assessment of gas and electrolytic composition of venous blood in patients with chronic obstructive pulmonary disease (COPD) in relation to basic parameters of functional state of kidneys. Methods: 60 patients with COPD were divided into low and high exacerbation risk groups and were examined. Standard examinations were carried out; electrolytic and gas composition of venous blood and kidney functions were assessed. Results: Patients with high risk of COPD exacerbation demonstrated symptoms of respiratory failure, hyperchloremia, higher levels of potassium and albuminuria; there was a relationship between albuminuria and oximetric parameters. A significant dependence between glomerular filtration rate and COPD exacerbation rate was not detected, but there was its relationship with the smoking index, the result of the CAT questionnaire, Gensler index, instantaneous expiratory flow rate, lung capacity and peak expiratory flow rate were recorded. Conclusions: COPD is often characterized by combination of gas and electrolytic composition imbalance of venous blood and renal dysfunction. With a high risk of exacerbations, signs of respiratory failure, hyperchloremia, higher levels of potassium and albuminuria are more often observed. The relationship between daily albuminuria and oximetric parameters, glomerular filtration rate and partial blood oxygen tension, found in people at high risk of COPD exacerbation may indicate the need for correction of blood gas composition to prevent renal dysfunction.