Correlation between statherin concentration in saliva and oral cavity diseases
https://doi.org/10.34215/1609-1175-2020-2-49-51
Abstract
Objective: Analysis of correlation between statherin concentration in saliva and oral cavity diseases. Methods: 134 patients aged 18–42 years were examined including 54 patients with caries and periodontitis and 80 patients without oral cavity diseases (control group). The concentration of statherin in saliva was determined by enzyme-linked immunosorbent assay. For statistical processing, the criteria of Shapiro–Wilk, Kraskel–Wallis, Mann–Whitney were used. The data are presented as the median, lower and upper quartiles in the format Me (Q1-Q3). Results: The average content of statherin in saliva in patients with an oral pathology was 13.4 (4.6–32) mmol/L, and in healthy saliva, it was 3.5 (2.9–7.3) mmol/L. Moreover, the control group demonstrated samples (9 %) in which statherin was absent. Conclusions: The presence of high concentrations of statherin in the oral fluid can be considered as a sign of an oral cavity disease.
About the Authors
R. A. Saleev
Kazan State Medical University
Russian Federation
Russian Federation
Rinat A. Saleev, MD, PhD, professor, Prosthetic Dentistry Department
49 Butlerova St., Kazan, 420012
D. A. Iavgildina
Kazan State Medical Academy (Branch Campus of the Russian Medical Academy of Continuous Professional Education)
Russian Federation
Kazan
Russian Federation
Kazan
References
1. Danilevskiy NF, Borisenko AV. Periodontal Diseases. Kiev: Zdorovye; 2000 (in Russ).
2. Humphrey SP, Williamson RT. A review of saliva: Normal composition, flow, and function. J Prosthet Dent. 2001;85:162–9.
3. Lawrence HP. Salivary markers of systemic disease: Noninvasive diagnosis of disease and monitoring of general health. J Can Dent Assoc. 2002;68:170–4.
4. Isola M, Cabras T, Inzitari R,. Lantini MS, Proto E, Cossu M, Riva A. Electron microscopic detection of statherin in secretory granules of human major salivary glands. J Anat. 2008;212(5):664–8.
5. Akutsu T, Watanabe K, Fujinami Y, Sakurada K. Applicability of ELISA detection of statherin for forensic identification of saliva. Int J Legal Med. 2010;124(5):493–8.
6. Isola M, Cossu M, Massa D, Casti A, Solinas P, Lantini MS. Electron microscopic immunogold localization of statherin in human minor salivary glands. J Anat. 2010; 216(5): 572–576.
7. Shimotoyodome A, Kobayashi H, Tokimitsu I, Matsukubo T, Takaesu Y. Statherin and histatin 1 reduce parotid saliva-promoted Streptococcus mutans strain MT8148 adhesion to hydroxyapatite surfaces. Caries Res. 2006;40(5):403–11.
8. Li T., Johansson I., Hay D.I., Stromberg N. Strains of Actinomyces naeslundii and Actinomyces viscosus exhibit structurally variant fimbrial subunit proteins and bind to different peptide motifs in salivary proteins. Infect Immun. 1999;67(5):2053–9.
9. Sekine S, Kataoka K, Tanaka M, Nagata H, Kawakami T, Akaji K, et al. Active domains of salivary statherin on apatitic surfaces for binding to Fusobacterium nucleatum cells. Microbiology. 2004;150(7):2373–9.
Review
For citations:
Saleev R.A., Iavgildina D.A. Correlation between statherin concentration in saliva and oral cavity diseases. Pacific Medical Journal. 2020;(2):49-51. (In Russ.) https://doi.org/10.34215/1609-1175-2020-2-49-51
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