The level of oxidative stress in rat brain tissue after a brain trauma injury with introduction of synthetic regulatory peptides
https://doi.org/10.34215/1609-1175-2020-3-65-67
Abstract
Objective: Comparative evaluation of the effect of regulatory peptides on lipid peroxidation in brain tissue after traumatic brain injury (TBI).
Methods: Reproductive Wistar male rats were divided into 3 groups: the first group received 0.1 mg/kg of “Selang” peptide solution (Thy-Lys-Pro-Arg-Pro-Gly-Pro) within 5 days after the experimental traumatic brain injury, the second group received 0.1 mg/kg AGAPGP peptide (Arg-Gly-Arg-Pro-Gly-Pro), the third (control) – 0.9% sodium chloride solution. Drugs were administered retroperitoneally.
Results: According to chemiluminescence in the biomaterial taken from rats of the first group, indicators of oxidative stress were less pronounced.
Conclusions: The Selang has a more pronounced antioxidant effect on brain tissue after traumatic brain injury compared with the AGAPGP peptide.
About the Authors
A. A. Kolesnikova
Far-Eastern State Medical University
Russian Federation
Russian Federation
MD, senior lecturer, Department of Pharmacy and Pharmacology,
35 Muravyov-Amursky St., Khabarovsk, 680000
M. Yu. Fleishman
Far-Eastern State Medical University
Russian Federation
Russian Federation
MD, PhD, chief research officer, Central Research Laboratory,
35 Muravyov-Amursky St., Khabarovsk, 680000
N. Yu. Yakusheva
Far-Eastern State Medical University
Russian Federation
Russian Federation
PhD, associate professor, Department of Pharmacy and Pharmacology,
35 Muravyov-Amursky St., Khabarovsk, 680000
E. V. Slobodenyuk
Far-Eastern State Medical University
Russian Federation
Russian Federation
PhD, chief of the Department of Pharmacy and Pharmacology,
35 Muravyov-Amursky St., Khabarovsk, 680000
I. V. Tolstenok
Far-Eastern State Medical University
Russian Federation
Russian Federation
PhD, associate professor, Department of Chemistry,
35 Muravyov-Amursky St., Khabarovsk, 680000
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Review
For citations:
Kolesnikova A.A., Fleishman M.Yu., Yakusheva N.Yu., Slobodenyuk E.V., Tolstenok I.V. The level of oxidative stress in rat brain tissue after a brain trauma injury with introduction of synthetic regulatory peptides. Pacific Medical Journal. 2020;(3):65-67. (In Russ.) https://doi.org/10.34215/1609-1175-2020-3-65-67
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