Key factors of inflammation and long-term prognosis in patients with myocardial infarction and visceral obesity
https://doi.org/10.34215/1609-1175-2020-3-77-82
Abstract
Objective: To assess the relation between key factors of inflammation and myocardial infarction complications in different stages of the diseases in patients with visceral obesity.
Methods: Men with the diagnosed myocardial infarction were examined: 64 of them with visceral obesity (the first group) and 30 of them without visceral obesity (the second group). On the 1s t and 12th day of hospitalization, the serum concentrations of interleukins (IL) 1β, 6, 8, 10 and 12, tumor necrosis factor α (TNFα) and C-reactive protein (CRP) were determined. The control group included 30 healthy men.
Results: The cytokine profile in visceral obesity was characterized by the increase in concentration of proinflammatory ILs and the decrease in concentration of IL-10. The concentration increase was: 1.3 times for IL-1 and TNFα, 2 times for IL-12, 6 times for IL-6 and 24 times for IL-8 and CRP. The increase in IL-6 and CPR levels in blood serum was associated with the obesity.
Conclusions: The development of adverse cardio‑ vascular complications a year later after the previous myocardial infarction is typical for patients with visceral obesity and is followed by the activation of proinflammatory cytokines and deficiency of IL-10.
About the Authors
E. G. Uchasova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
MD, PhD, senior researcher,
6 Sosnovyi Blvd, Kemerovo, 650002
E. V. Belik
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
MD, junior researcher,
6 Sosnovyi Blvd, Kemerovo, 650002
O. V. Gruzdeva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
MD, PhD, head of the Laboratory for Homeostasis,
6 Sosnovyi Blvd, Kemerovo, 650002
Y. A. Dileva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
MD, PhD, senior researcher,
6 Sosnovyi Blvd, Kemerovo, 650002
A. A. Kuzmina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
MD, junior researcher,
6 Sosnovyi Blvd, Kemerovo, 650002
References
1. Alexopoulos N, Katritsis D, Raggi P. Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis. Atherosclerosis. 2014;233(1):104–12.
2. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11(2):85–97.
3. Odegaard JI, Chawla A. Pleiotropic actions of insulin resistance and inflammation inmetabolic homeostasis. Science. 2013;339:172–7.
4. Bruun JM, Lihn AS, Pedersen SB, Richelsen B. Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab. 2005;90(4):2282–9.
5. Ahmad R, Al-Mass A, Atizado V, Al-Hubail A, Al-Ghimlas F, Al-Arouj M, et al. Elevated expression of the toll like receptors 2 and 4 in obese individuals: Its significance for obesity-induced inflammation. J Inflamm. 2012;9:48. doi: 10.1186/1476-9255-9-48
6. Lee JY, Zhao L, Youn HS, Weatherill AR, Tapping R, Feng L, et al. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem. 2004;1279(17):16971–9.
7. Gruzdeva OV, Barbarash OL, Palicheva EI, Dyleva YA, Kashtalap VV, Polikutina OM, Akbasheva ОЕ. The role of free fatty acids in the development of clinical complications of atherosclerosis. Ateroskleroz. 2011;1:19–25 (In Russ).
8. Satoh M, Shimoda Y, Akatsu T, Ishikawa Y, Minami Y, Nakamura M. Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction. Eur J Heart Fail. 2006;8(8):810–5.
9. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796–808. 10. Moschen AR, Molnar C, Enrich B, Geiger S, Ebenbichler CF, Tilg H. Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss. Mol Med. 2011;17(7–8):840–5.
10. Fain JN, Bahouth SW, Madan AK. Involvement of multiple signaling pathways in the post bariatric induction of IL‐6 and IL‐8 mRNA and release in human visceral adipose tissue. Biochem Pharmacol. 2005;69(9):1315–24.
11. Makki K, Froguel P, Wolowczuk I. Adipose tissue in obesity-related inflammation and insulin resistance: Cells, cytokines, and chemokines. ISRN Inflamm. 2013;139239. doi: 10.1155/2013/139239
12. Bruun JM, Lihn AS, Madan AK, Pedersen SB, Schiøtt KM, Fain JN, Richelsen B. Higher production of IL‐8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue. Am J Physiol Endocrinol Metab. 2004;286:8–13.
13. Hansson GK, Robertson AK, Söderberg-Nauclér C. Inflammation and atherosclerosis. Annu Rev Pathol. 2006;1:297–329.
Review
For citations:
Uchasova E.G., Belik E.V., Gruzdeva O.V., Dileva Y.A., Kuzmina A.A. Key factors of inflammation and long-term prognosis in patients with myocardial infarction and visceral obesity. Pacific Medical Journal. 2020;(3):77-82. (In Russ.) https://doi.org/10.34215/1609-1175-2020-3-77-82
Views:
477
Email this article 