Treatment of brain tumors by the method of the boron neutron capturing therapy: challenges and modern solutions
Abstract
The article introduces the method of boron neutron capturing therapy (BNCT) and its potential clinical application for treatment of malignant brain tumors. The analysis and literature review of the use of BNCT in the world, citing statistics on the survival rate of patients with brain tumor after a session of BNCT. Comparative characteristics of various neutron sources used for BNCT in the world. A review of pharmacological agents used in BNCT as a delivery agent 10B. Based on the review of the literature produced outlining the recognized problems of the method. We consider the two challenges for clinical implementation of BNCT - create an independent source of epithermal neutrons and selective delivery of boron-containing drugs to the central nervous system. Analysis of the solution of these difficulties is complemented by the results of development and experimental data of the laboratory of BNCT of Budker Institute of Nuclear Physics.
About the Authors
A. I. Yarullina
Budker Institute of Nuclear Physics; Irkutsk State Medical University
Russian Federation
Russian Federation
V. V. Kanygin
Budker Institute of Nuclear Physics; Novosibirsk State Medical University; Railway Clinical Hospital on the station Novosibirsk
Russian Federation
Russian Federation
A. I. Kichigin
Budker Institute of Nuclear Physics; Railway Clinical Hospital on the station Novosibirsk
Russian Federation
Russian Federation
M. G. Zhdanova
Budker Institute of Nuclear Physics
Russian Federation
Russian Federation
R. A. Mukhamadiyarov
Scientific Research Institute of Complex Problems of Cardiovascular Diseases
Russian Federation
Russian Federation
S. Ju. Taskaev
Budker Institute of Nuclear Physics; Novosibirsk State University
Russian Federation
Russian Federation
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Review
For citations:
Yarullina A.I., Kanygin V.V., Kichigin A.I., Zhdanova M.G., Mukhamadiyarov R.A., Taskaev S.J. Treatment of brain tumors by the method of the boron neutron capturing therapy: challenges and modern solutions. Pacific Medical Journal. 2015;(4):4-10. (In Russ.)
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