Osteoreparation features using biomaterials based on hydroxyapatite and strontium-substituted hydroxyapatite
Abstract
Background. Research objective is a comparative analysis of bone tissue regeneration in vivo after implantation original calciumphosphate materials. Methods. In the experiment on male rats, the samples of hydroxyapatite and strontium-substituted hydroxyapatite were implanted on the surface of the created defect of tibia. Histological examination of the material was held in a month. Results. It is found that using these materials allows full substitution of bone defect, boost the formation and differentiation of bone tissue, strengthen mineralization of newly formed osteons, and caused minimal destructive reorganization in intact areas. Conclusions. The studied materials can be considered as promising inorganic structures for regenerative medicine.
About the Authors
M. A. Medkov
Chemistry Institute FEB RAS
Russian Federation
Russian Federation
D. N. Grischenko
Chemistry Institute FEB RAS
Russian Federation
Russian Federation
V. S. Rudnev
Chemistry Institute FEB RAS; Far Eastern Federal University
Russian Federation
Russian Federation
I. V. Shulepin
Pacific State Medical University
Russian Federation
Russian Federation
A. S. Cherepovskiy
Pacific State Medical University
Russian Federation
Russian Federation
A. I. Ponomarenko
Pacific State Medical University
Russian Federation
Russian Federation
I. V. Dyuizen
Pacific State Medical University; Marine Biology Insitute FEB RAS
Russian Federation
Russian Federation
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Review
For citations:
Medkov M.A., Grischenko D.N., Rudnev V.S., Shulepin I.V., Cherepovskiy A.S., Ponomarenko A.I., Dyuizen I.V. Osteoreparation features using biomaterials based on hydroxyapatite and strontium-substituted hydroxyapatite. Pacific Medical Journal. 2015;(4):48-52. (In Russ.)
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