CD56 and CD57 expression by distinct populations of human cytotoxic T lymphocytes
Abstract
Background. Cytotoxic T cell subsets with distinct homing potentials, phenotype and effector functions play an important part in many chronic viral infections and autoimmune diseases. Methods. Using 10-color flow cytometry we characterized cytotoxic T cell subsets based on expression of CD45RA, CD62L, CD27, and CD28 and compared the expression of CD56 and CD57 between these subsets. Results. It was shown that CD56 positive cells were predominantly immature T-cells, expressing CD27 and/or CD28. CD57 was found mainly on the cell membrane of most mature populations, lacking CD27 or both co-stimulation molecules. Co-expression of both antigens was determined exclusively on the most mature populations of T cells, which belonged to effector memory (CD45RA-CD62L-) and terminally differentiated effectors (cD45RA+CD62L+) CD3+CD8+ lymphocytes. Conclusions. According to our data in peripheral blood we can identify several populations of cytotoxic T cell with similar properties
About the Authors
I. V. Kudryavtsev
School of Biomedicine of Far Eastern Federal University, Institute of Experimental Medicine
Russian Federation
Russian Federation
A. G. Borisov
Scientific Research Institute of Medical Problems of the North
Russian Federation
Russian Federation
A. E. Volkov
School of Biomedicine of Far Eastern Federal University
Russian Federation
Russian Federation
A. A. Savchenko
Scientific Research Institute of Medical Problems of the North
Russian Federation
Russian Federation
M. K. Serebryakova
Institute of Experimental Medicine
Russian Federation
Russian Federation
A. V. Polevschikov
School of Biomedicine of Far Eastern Federal University, Institute of Experimental Medicine
Russian Federation
Russian Federation
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Review
For citations:
Kudryavtsev I.V., Borisov A.G., Volkov A.E., Savchenko A.A., Serebryakova M.K., Polevschikov A.V. CD56 and CD57 expression by distinct populations of human cytotoxic T lymphocytes. Pacific Medical Journal. 2015;(2):30-35. (In Russ.)
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