Condition of energy metabolism of rat cerebrum on the background of some liquids infusions under ischemia reperfusion

Abstract

Background. Among the remedial measures that reduce the intensity of cerebral ischemia in acute cerebrovascular disorders, one of the main places takes infusion therapy. Methods. An experimental model of ischemia reperfusion in rats was made by the putting of the clamp on the internal carotid artery for 20 minutes. Cerebroprotectors - 0.9 % NaCl, HAES-LX-5 % and Voluven - was injected intravenously 2.5 ml/kg 2 times per day for 7-days. Control Group dos not receive any treatment. Cerebrum homogenate was tested for adenine nucleotides and glucose metabolites. Results. Experimental therapy liquids of HAES-LX-5 % and Voluven suppress the formation of cerebrum energy deficiency. Compared with 0,9 % NaCl, useing of these drugs accompanied by a more essential reduction of energy deficiency, the processes of anaerobic glycolysis and by the improvement of aerobic glucose oxidation in ischemic cerebrum. Cobclusions. HAES-LX-5 % and Voluven among themselves are almost equal in their ability to reduce the manifestations of energy deficiency and influence to the processes of anaerobic glycolysis and aerobic oxidation of glucose. The effect of the experimental treatment is the basis for further study of the protective effect of these drugs in acute cerebrovascular disorders.