Assessing of the Histochrome impact on morphometric parameters of the optic disk in the treatment of primary open-angle glaucoma

Abstract

Background. Assessment of the efficiency of glaucoma combined therapy with using of Histochrome during sinus trabeculectomy (STE) in the early postoperative period, in combination with the magnetotherapy. Methods. The study included 51 patients with primary open-angle glaucoma I-III stage with moderately elevated intraocular pressure. In 25 cases, combined with the use of STE Histochrome and magnetotherapy (treatment group), in 26 cases been conducted standart SHE (control group). All patients before the treatment and after 3 and 6 months after treatment been given complete ophthalmologic examination, including the Heidelberg retinal tomography. Results. In the treatment group been detected the decrease of area and volume of excavation, the ratio of the area of optic disc to excavation, linear diameter relation of excavation to the optic nerve, the mean and maximum depths of excavation. At the same time shown itself, the increase of area and volume of neuroretinal rim, mean thickness and cross sectional area of the nerve fiber layer. In the control group, statistically significant changes in these parameters were not observed. Conclusions. The proposed method of treatment of open-angle glaucoma gives positive effect with improved by 20-45 % from baseline in most parameters and also on the III stage of disease. This therapy, taking into account the severity of the problem, could be recommended for widespread introduction into clinical practice.