EXPERIMENTAL STUDY OF THE ANALGESIC ACTIVITY OF ACONITUM KUZNEZOFFI REICHENB
Abstract
One of the urgent problems of modern pharmacology is the development of high-efficiency low-dose analgesics. Promising direction is the development of drugs based on the diterpene alkaloids produced by Ranunculaceous family plants. Methods. For the experimental study of the analgesic activity of a standardized alkaloid-containing aconite extract (Aconitum Kuznezoffi Reichenb. - Ranunculaceae Juss.) the researchers used screening models of thermic (Hot plate) and chemical (Abdominal constriction test) impact of pain. Results. In the test “hot plate” there was revealed a pronounced analgesic effect of the Aconitum Kuznezoffi Reichenb. in intragastric course use. On the model of chemical pain stimulation in the peritoneum the phyto-drug showed analgesic activity comparable with the effect of indometacin. Conclusions. Aconite extract showed a mixed type of receptor response on the models with different profile of pain stimulation that allows to include it into a group of promising highly active analgesics with a complex mechanism of action.
About the Authors
S. G. Krylova
E.D. Goldberg Research Institute of Pharmacology, Siberian Branch of RAMS
Russian Federation
Russian Federation
P. S. Zorikov
V.L. Komarov Gornotaezhnaya station, Far Eastern Branch of RAS
Russian Federation
Russian Federation
E. P. Zueva
E.D. Goldberg Research Institute of Pharmacology, Siberian Branch of RAMS; National Research Tomsk State University
Russian Federation
Russian Federation
T. G. Razina
E.D. Goldberg Research Institute of Pharmacology, Siberian Branch of RAMS
Russian Federation
Russian Federation
E. N. Amosova
E.D. Goldberg Research Institute of Pharmacology, Siberian Branch of RAMS
Russian Federation
Russian Federation
O. Yu. Rybalkina
E.D. Goldberg Research Institute of Pharmacology, Siberian Branch of RAMS
Russian Federation
Russian Federation
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Review
For citations:
Krylova S.G., Zorikov P.S., Zueva E.P., Razina T.G., Amosova E.N., Rybalkina O.Yu. EXPERIMENTAL STUDY OF THE ANALGESIC ACTIVITY OF ACONITUM KUZNEZOFFI REICHENB. Pacific Medical Journal. 2014;(2):38-40. (In Russ.)
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