EFFECT OF IODIDE-BROMINE BATHS ON THE MACROPHAGE SYSTEM CELLS IN WOMEN WITH CLIMACTERIC SYNDROME

Abstract

Ovarian dysfunction in perimenopause is characterized by increased level of follicle-stimulating hormone. Estrogens and progesterone, in turn, are able to interact with macrophages through their receptors to the steroid hormones. Methods. The authors studied the effect of iodide-bromine baths on the stability status of lysosomal membrane blood monocytes and peritoneal macrophages, secretory synthetic activity of these cells in 39 women of 45-52 years old: 16 healthy (control) and 23 with vegetative climacteric syndrome treated with iodide-bromine baths. Results. The women of the second group have been registered with labialization of lysosomal macrophages membranes, increasing their secretion of lysozyme while reducing its synthesis. Use of iodide-bromine baths led to the stabilization of these indicators and contributed disappearance or reduction of climacteric syndrome. Conclusions. The data obtained allow to expand the understanding of the mechanisms of action of balneotherapy on macrophage cells and conclude that the course application of iodide-bromine baths not only reduces the intensity of the symptoms of the climacteric syndrome, but also makes adjustments to the immune system in perimenopause.