Биосовместимые матриксные имплантаты на основе природных и синтетических полимеров как перспективные средства для терапии дегенеративных и посттравматических заболеваний центральной нервной системы
Аннотация
Обзор современных исследований и разработок в области создания биосовместимых имплантируемых материалов для терапии дегенеративных и посттравматических патологий центральной нервной системы. Проведен критический анализ материалов и их компонентов на основе природных и синтетических полимеров, применение которых в качестве матриксных имплантатов может способствовать восстановлению целостности поврежденного мозга, осуществлению заместительных и трофических функций, индукции репаративных процессов за счет внутренних и имплантируемых клеточных источников. Современное состояние биомедицинского материаловедения и тканевой инженерии для нужд нейротрансплантологии охарактеризовано в форме анализа способности материалов имитировать структуры и функции естественного внеклеточного матрикса, индуцировать нейрогенез и восстановление проводниковых функций нервной системы, а также способности материалов подвергаться контролируемой биодеградации с последующим замещением тканевыми структурами организма.
Об авторах
Ю. С. Хотимченко
Институт биологии моря им. А.В. Жирмунского Дальневосточного отделения РАН; Дальневосточный федеральный университет
Россия
Россия
А. В. Щеблыкина
Институт биологии моря им. А.В. Жирмунского Дальневосточного отделения РАН
Россия
Россия
В. В. Кумейко
Институт биологии моря им. А.В. Жирмунского Дальневосточного отделения РАН; Дальневосточный федеральный университет
Россия
Россия
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Рецензия
Для цитирования:
Хотимченко Ю.С., Щеблыкина А.В., Кумейко В.В. Биосовместимые матриксные имплантаты на основе природных и синтетических полимеров как перспективные средства для терапии дегенеративных и посттравматических заболеваний центральной нервной системы. Тихоокеанский медицинский журнал. 2012;(2):54-60.
For citation:
Khotimchenko Yu.S., Scheblyikina A.V., Kumeiko V.V. BIOCOMPATIBLE MATRIX IMPLANTS FROM NATURAL AND SYNTHETIC POLYMERS AS PROMISING PRODUCTS INTENDED FOR TREATMENT OF DEGENERATIVE AND POST-INJURY DISEASES OF CENTRAL NERVOUS SYSTEM. Pacific Medical Journal. 2012;(2):54-60. (In Russ.)
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