Reduction of mineral density of bone tissue as cardiovascular remodelling marker
Abstract
The paper provides the study of correlation between heart remodelling indices and mineral density of bone tissue (BMD). The authors have examined 205 women in postmenopausal period, among which 60 women suffered from arterial hypertension and osteoporosis, 43 women suffered from arterial hypertension and normal BMD, 52 women were normotensive with osteoporosis, and 50 women were normotensive with normal BMD. The authors have established the interrelation between BMD and cardiovascular remodelling factors and shown that BMD reduction is a marker of unfavourable concentric variants of heart remodelling, disorder of diastolic ventricular filling by hypertrophic type and increase in “intima-media” complex of carotid arteries.
About the Authors
N. Yu. Khoziainova
Smolensk State Medical Academy
Russian Federation
Russian Federation
V. M. Tsareva
Smolensk State Medical Academy
Russian Federation
Russian Federation
Yu. V. Kurbasova
Smolensk State Medical Academy
Russian Federation
Russian Federation
N. V. Romanchenko
Smolensk Oblast Clinical Hospital
Russian Federation
Russian Federation
O. V. Petrushchenkova
Outpatient Department No. 4, Smolensk
Russian Federation
Russian Federation
References
1. Мазуров В.И., Столов С.В., Якушева В.А. Кардиоваскулярные проблемы в ревматологии // Научно-практическая ревматология. 2006. № 4. С. 28-34.
2. Маличенко С.Б., Колосова И.Р., Варежкина И.А. Первичный остеопороз: взаимосвязь патологии костной и сердечнососудистой системы у пожилых // Consilium Medicum. 2004. Т. 6, № 12. С. 1032-1043.
3. Назаренко Г.И., Андронова О.В., Анохин В.Н. Дегенеративный (кальцинированный) аортальный стеноз, атеросклероз и остеопороз: клинико-морфологические параллели // Клиницист. 2006. № 1. С. 11-18.
4. Ревматология: национальное руководство / под ред. Насонова Е.Л., Насоновой В.А. М.: ГЭОТАР-Медиа, 2008. 380 с.
5. Руководство по медицинской профилактике / под ред. Оганова Р.Г., Хальфина Р.А. М.: ГЭОТАР-Медиа, 2007. 460 с.
6. Скрипникова И.А., Поддубская Е.И., Берзак Н.В., Рубченко Т.И. Современные подходы к диагностике и профилактике остеопороза и сердечно-сосудистых заболеваний у женщин с естественной и искусственной менопаузой // Профилактика и укрепление здоровья. 2006. № 4. С. 7-15.
7. Doherty T., Fitzpatrick L., Inoue F. Molecular, endocrine, genetic mechanisms of arterial calcification // Endocr. Rev. 2004. Vol. 25. P. 629-672.
8. Hofbauer L., Schoppet M. Clinical implications of the osteoprotegerin RANKL/RANK system for bone and vascular diseases // JAMA. 2004. Vol. 292. P.490-495.
9. Kiechl S., Schett G., Wenning G. et al. Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease // Circulation. 2004. Vol. 109. P. 2175-2180.
10. McFarlane S.I., Muniyappa R., Shin J.J. et al. Osteoporosis and cardiovascular disease: brittle bones and boned arteries - is there a link? // Endocrinology. 2004. Vol. 23. P. 1-10.
11. Tanko L.B., Christiansen C., Cox D.A. et al. Relationship between osteoporosis and cardiovascular disease in postmenopausal women // J. Bone Miner. Res. 2005. Vol. 20. P. 1912-1920.
12. Trone D.W., Kritz-Silverstein D., von Muhlen D.G. et al. Is radiographic vertebral fracture a risk factor for mortality? // Am. J. Epidemiol. 2007. Vol. 166, No. 10. P. 1191-1197.
Review
For citations:
Khoziainova N.Yu., Tsareva V.M., Kurbasova Yu.V., Romanchenko N.V., Petrushchenkova O.V. Reduction of mineral density of bone tissue as cardiovascular remodelling marker. Pacific Medical Journal. 2011;(4):58-61. (In Russ.)
Views:
261
Email this article 