Pathogenetic and clinical aspects of forming alimentary intolerance in children
Abstract
To this day, all pathogenetic mechanisms of forming alimentary intolerance in children, the influence of the child’s organism responsiveness, issues of treatment and prevention remain unstudied. The authors have conducted an integrated clinico-immunological, biochemical and functional examination in dynamics of 39 children with lactase insufficiency aged 1.5 to 12 months, and found out the formation of alimentary intolerance of lactose in children has been associated with digestive disorders at all stages: abdominal, wall and intracellular digestion with the modified state of mucosal immunity, the bowels microbiota and imbalance in the production of pro-inflammatory and anti-inflammatory cytokines. Studying non-specific factors for the protection of mucous tunic of the digestive tract, features of mucosal immunity is very promising to decode the pathogenesis of the alimentary intolerance in children and to develop algorithms for treating and preventing this pathology.
About the Authors
T. A. Shumatova
Vladivostok State Medical University
Russian Federation
Russian Federation
N. G. Prikhodchenko
Vladivostok State Medical University
Russian Federation
Russian Federation
L. A. Grigoryan
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Shumatova T.A., Prikhodchenko N.G., Grigoryan L.A. Pathogenetic and clinical aspects of forming alimentary intolerance in children. Pacific Medical Journal. 2011;(2):62-65. (In Russ.)
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