The role of computer-held morphometry of ribosome nucleolar jrganizer zones in the algorithm of treatment of hatients with prostatic intraepithelial neoplasms
Abstract
The authors have been searching for factors of an increased risk of prostate cancer in patients with high-grade prostatic intraepithelial neoplasm known to be its most probable precursor. The authors decided to apply computer-assisted morphometry of the ribosome nucleolar organizer zones in 36 biopsy specimens of the prostate gland with the sites of high-degree prostatic intraepithelial neoplasms. The cancer has not been diagnosed in all cases during re-biopsy of patients with 1 and 2 epithelium hystotypes. The prostate gland cancer has been diagnosed in 7 cases (33%) in patients with 3 and higher epithelium hystotypes. Therefore, when diagnosing high-degree prostatic intraepithelial neoplasms, it is expedient to perform computer-assisted morphometry of the ribosome nucleolar organizer zones that is the most efficient method of predicting the progress of prostate gland cancer.
About the Authors
V. V. Gordeev
Khabarovsk-1 Railway Clinical Hospital, JSC “Russian Railways”
Russian Federation
Russian Federation
A. G. Antonov
Far Eastern State Medical University
Russian Federation
Russian Federation
A. N. Evseev
Far Eastern State Medical University
Russian Federation
Russian Federation
I. I. Kurunova
Khabarovsk-1 Railway Clinical Hospital, JSC “Russian Railways”
Russian Federation
Russian Federation
S. Yu. Kryizhanovskaya
Far Eastern State Medical University
Russian Federation
Russian Federation
S. V. Marshev
Khabarovsk-1 Railway Clinical Hospital, JSC “Russian Railways”
Russian Federation
Russian Federation
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Review
For citations:
Gordeev V.V., Antonov A.G., Evseev A.N., Kurunova I.I., Kryizhanovskaya S.Yu., Marshev S.V. The role of computer-held morphometry of ribosome nucleolar jrganizer zones in the algorithm of treatment of hatients with prostatic intraepithelial neoplasms. Pacific Medical Journal. 2011;(1):23-25. (In Russ.)
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