Pathogenetic fundamentals of simultaneous correction of erectile dysfunction and urination disorders
Abstract
Summary - The paper provides results of observations of 28 men aged 31 to 67 years suffering from the erectile dysfunction and urination disorders. The observations comprised of studies of the endocrine profile, in-home urofluometry aimed to estimate symptoms on IPSS, MIEF-5, and QOL scales. The treatment course included phosphodiesterase type 5 inhibitors (sildenafil citrate) administered for the period of 6 weeks as a monotherapy (25 mg per day in the evening), and then long-term treatment with the use of α1 adrenoceptor-blocking agents. The authors point out both restoration of the erectile function and considerable reduction of the urination disorders in all follow-ups. The findings allow to suggest a possibility of applying the phosphodiesterase type 5 inhibitors to eliminate erectile dysfunctions and simultaneous correction of urination disorders.
About the Authors
V. V. Danilov
Vladivostok State Medical University
Russian Federation
Russian Federation
A. V. Vasilchenko
Vladivostok State Medical University
Russian Federation
Russian Federation
T. I. Danilova
Vladivostok State Medical University
Russian Federation
Russian Federation
V. V. Danilov
Vladivostok State Medical University
Russian Federation
Russian Federation
S. V. Besedin
Vladivostok Station Departmental Hospital, JSC “Russian Railways”
Russian Federation
Russian Federation
References
1. Урофлоуметрия / Вишневский Е.Л., Пушкарь Д.Ю., Лоран О.Б. и др. М.: Печатный город, 2004. 220 с.
2. Behr-Roussel D., Gorny D., Mevel K. et al. Chronic sildenafil improves erectile function and endothelium-dependent cavernosal relaxations in rats: lack of ta-chyphylaxis // European Urology. 2005. Vol. 47, No. 1. P. 87-91.
3. Eardley I. Optimisation of PDE5 inhibitor therapy in men with erectile dysfunc-tion: converting “non-responders” into “responders” // European urology. 2006. Vol. 50, No. 1. P. 31-33.
4. El-Sakka A.I. Lower urinary tract symptoms in patients with erectile dysfunc-tion: is there a vascular association? // European Urology. 2005. Vol. 48, No. 2. P. 319-325.
5. Hoesl C.E., Woll E.M., Burkart M., Altwein J.E. Erectile dysfunction is preva-lent, bothersome and underdiagnosed in patients consulting urologists for benign prostatic syndrome // European Urology. 2005. Vol. 47, No. 4. P. 511-517.
6. Kaplan S.A., Gonzalez R., Ogiste J., Te A.E. Combination of an a1-blocker, al-fuzosin and a PDE5 inhibitor, sildenafil citrate, is superior to monotherapy in treating lower urinary tract symptoms and sexual dysfunction // European Urol-ogy Supplements. 2006. Vol. 5, No. 2. P. 197-197.
7. Mirone V., Costa P., Damber J.-E. et al. An evaluation of an alternative dosing regimen with tadalafil, 3 times/week, for men with erectile dysfunction: SURE study in 14 European countries // European Urology. 2005. Vol. 47, No. 6. P. 846-854.
8. Montorsi F., Briganti A., Saloni A. et al. Can Phosphodiesterase type 5 inhibitor cure erectile dysfunction? // European urology. - 2006. - Vol. 49, No. 6. P. 979-986.
9. Ng C.F., Wong Y.F., Wong H.M. et al. A prospective randomised crossover trial on the effect of vardenafil 10mg on blood pressure in patients with erectile dys-function who receive concomitant doxazosin gits for the treatment of benign prostatic hyperplasia // European Urology Supplements. 2008. Vol. 7, No. 2. P. 160.
10. Umul M., Altay B., Bademkiran F et al. Evaluating the relationship between lower urinary tract symptoms associated with bening proststic hyperplasia and erectile dysfunction: role of autonomic hyperactivity // European Urology Sup-plements. 2008. Vol. 7, No. 3. P. 160.
11. Zlotta A.R., Teillac P., Raynaud J.P., Schulman C.C. Evaluation of male sexual function in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia treated with a phytotherapeutic agent (Permixon), tamsulosin or finasteride // European Urology. 2005. Vol. 48, No. 2. P. 269-276.
Review
For citations:
Danilov V.V., Vasilchenko A.V., Danilova T.I., Danilov V.V., Besedin S.V. Pathogenetic fundamentals of simultaneous correction of erectile dysfunction and urination disorders. Pacific Medical Journal. 2011;(1):36-40. (In Russ.)
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