Immunological facets of anti-tumor action of water-soluble polysaccharides from Sweetflag Rhizome

The paper studies effects from water-soluble polysaccharides extracted from Sweetflag rhizome (WSPS-S) on the functional status of lymphocytes of mice with transplanted Lewis lung carcinoma, given the isolated introduction and in combination with cyclophosphan when testing Vinn tumour cells neutralization. The authors estimate the action of WSPS-S on the intensity of local inflammatory response and activity of macrophages of intact animals in vitro. The course infusion of WSPS-S makes the lymph node cells inhibit growth and dissemination of the tumour. The WSPS-S stimulates considerable inflammation induced by T-helpers type 1 and suppresses inflammation induced by T-helpers type 2. The in vitro effects include five-fold increase of the interleukin-12 production by macrophages with no changes observed with respect to the interleukin-10 production. As concluded, the WSPS-S inhibits growth of the primary tumour node and dissemination due to activation of M1 macrophage phenotype and inflammation change-over to T-helper type 1 immune response.

polysaccharides, interleukins, induced inflammation

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