Diagnostic and prognostic informativity of new lectin immunoenzymometric method for diagnosing cervical cancer

Abstract

Based upon 120 case follow-ups, the authors estimate efficiency of applying lectin immunoenzymometric method intended for differential diagnostics of benign and malignant neoplasms of uterine cervix, and analyze contents of lectin-related embryonic cancer and embryo-like cancer antigens in vaginal secretion. With this end in view, the authors use mannan-binding lectin of the Far-eastern sea cucumber Apostichopus japonicus to identify statistically reliable differences between the levels of lectin-binding antigens between healthy women and patients with cervical cancer, and between patients with benign and malignant neoplasms. The method sensitivity and specificity are 93.6 and 87.8%, respectively, given the cut-off level of 12.74 ng/ml. With all this in view, this method has more advantages compared to those associated with determining of concentration of embryonic cancer antigen and squamous cell carcinoma antigen in blood serum.