CYTOKINE IMBALANCE AS ONE OF PROGNOSTIC CRITERIA FOR DISSEMINATED SCLEROSIS COURSE
Abstract
Summary - The fact that the disseminated sclerosis belongs to autoimmune
diseases predominates dependence of its progression rate
on the cytokine imbalance. The authors study levels of relation between
pro-inflammatory and anti-inflammatory cytokines during
aggravation of the disease and in remission in 19 patients aged 20
to 58 with various types of the disseminated sclerosis course. As
reported, disseminated sclerosis is characterised by considerable
increase in 1 and 6 interleukin concentrations. It reaches its maximum
values during aggravation under low levels of interleukin-1
receptor antagonist and tumour necrosis factor-. There is a dependence
of these indices on the disease stage. The prognostic criteria
for disseminated sclerosis are interleukin-1/nterleukin-1 receptor
antagonist and tumour necrosis factor- concentration
diseases predominates dependence of its progression rate
on the cytokine imbalance. The authors study levels of relation between
pro-inflammatory and anti-inflammatory cytokines during
aggravation of the disease and in remission in 19 patients aged 20
to 58 with various types of the disseminated sclerosis course. As
reported, disseminated sclerosis is characterised by considerable
increase in 1 and 6 interleukin concentrations. It reaches its maximum
values during aggravation under low levels of interleukin-1
receptor antagonist and tumour necrosis factor-. There is a dependence
of these indices on the disease stage. The prognostic criteria
for disseminated sclerosis are interleukin-1/nterleukin-1 receptor
antagonist and tumour necrosis factor- concentration
About the Authors
С. Гуляева
Владивостокский государственный медицинский университет
Россия
Россия
Л. Иванушко
НИИ эпидемиологии и микробиологии СО РАМН
Россия
Россия
А. Овчинников
Владивостокский государственный медицинский университет
Россия
Россия
Н. Беседнова
Владивостокский государственный медицинский университет
Россия
Россия
М. Короткова
Владивостокский государственный медицинский университет
Россия
Россия
В. Шаркова
Владивостокский государственный медицинский университет
Россия
Россия
О. Фомина
Владивостокский государственный медицинский университет
Россия
Россия
А. Овчинникова
Владивостокский государственный медицинский университет
Россия
Россия
S. E. Gulyaeva
Vladivostok State Medical University
Россия
Россия
L. A. Ivanushko
Research Institute of Epidemiology and
Microbiology, Siberian Branch of RAMS
Россия
Россия
A. V. Ovchinnikova
Vladivostok State Medical University
Россия
Россия
N. A. Besednova
Vladivostok State Medical University
Россия
Россия
M. A. Korotkova
Vladivostok State Medical University
Россия
Россия
V. A. Sharkova
Vladivostok State Medical University
Россия
Россия
O. I. Fomina
Vladivostok State Medical University
Россия
Россия
A. A. Ovchinnikova
Vladivostok State Medical University
Россия
Россия
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Review
For citations:
, , , , , , , , Gulyaeva S.E., Ivanushko L.A., Ovchinnikova A.V., Besednova N.A., Korotkova M.A., Sharkova V.A., Fomina O.I., Ovchinnikova A.A. CYTOKINE IMBALANCE AS ONE OF PROGNOSTIC CRITERIA FOR DISSEMINATED SCLEROSIS COURSE. Pacific Medical Journal. 2010;(4):55-58. (In Russ.)
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