POLYMORPHISM OF GLUTATHIONE TRANSFERASE GENES IN CASE OF CHRONIC OBSTRUCTIVE LUNG DISEASE ASSOCIATED WITH ISCHEMIC HEART DISEASE
Abstract
Applying polymerase chain reaction, the authors have studied distribution of polymorphous variants of genes responsible for coding glutathione transferases (GSTM1 и GSTT1) in 60 patients with chronic obstructive lung disease associated with stable angina and 30 healthy men and detected high frequency of homozygous deletions of these genes. The zero genotype GSTT1 is reliably indicative of the severity of lung pathology. The associated deletion genotype GSTM1 and GSTT1 is characterized by increasing relative risk of a combined pathology of heart and lungs. Detection of molecular genetic markers will make it possible to apply them for identifying risk groups and implementing
prevention of chronic obstructive lung disease and ischemic heart disease.
prevention of chronic obstructive lung disease and ischemic heart disease.
Keywords
575.174.015.3:577.152.2]:[616.233-002-036.12+616.12-005.4
About the Authors
Т. Тилик
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
В. Невзорова
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
С. Вахрушева
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
Е. Панченко
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
М. Исаева
ихоокеанский институт биоорганической химии ДВО РАН
Russian Federation
Russian Federation
T. V. Tilik
Vladivostok State Medical University
Russian Federation
Russian Federation
V. A. Nevzorova
Vladivostok State Medical University
Russian Federation
Russian Federation
S. E. Vakhrusheva
Vladivostok State Medical University
Russian Federation
Russian Federation
E. A. Panchenko
Vladivostok State Medical University
Russian Federation
Russian Federation
M. P. Isaeva
Pacific Institute of Bioorganic Chemistry of FEB RAS
Russian Federation
Russian Federation
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, , , , , Tilik T.V., Nevzorova V.A., Vakhrusheva S.E., Panchenko E.A., Isaeva M.P. POLYMORPHISM OF GLUTATHIONE TRANSFERASE GENES IN CASE OF CHRONIC OBSTRUCTIVE LUNG DISEASE ASSOCIATED WITH ISCHEMIC HEART DISEASE. Pacific Medical Journal. 2010;(1):13-15. (In Russ.)
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