IMMUNE STATUS OF CHILDREN WITH CHRONIC VIRAL HEPATITIS B AND C
Abstract
The paper considers the state of immune status in 52 children aged 12 to 17 with chronic viral hepatitis B and C. The immune system changes do not depend on etiological agent and are characterized by decreasing cell and increasing humoral immunity responsiveness. Besides, the patients suffering from chronic viral hepatitis C have the natural killers content reduced that leads to more apparent decrease in the virus protection level.
About the Authors
И. Соловьева
Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого
Russian Federation
Russian Federation
А. Савченко
НИИ медицинских проблем Севера СО РАМН
Russian Federation
Russian Federation
Г. Мартынова
Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого
Russian Federation
Russian Federation
I. A. Soloviova
Krasnoyarsk State Medical University named after V.F. Voino-Yasenetsky
Russian Federation
Russian Federation
A. A. Savchenko
Research Institute of Medical Problems of the North, Siberian branch of the RAMS
Russian Federation
Russian Federation
G. P. Martyinova
Krasnoyarsk State Medical University named after V.F. Voino-Yasenetsky
Russian Federation
Russian Federation
References
1. Арямкина О.Л. Хроническая HBV- и HCV- инфекция и рак печени: клинико-эпидемиологические и дифференциально-диагностические параллели // Эпидемиол. и инфекц. болезни. 2006. № 2. С. 36-39.
2. Земсков А.М., Земсков В.М. Дополнительные методы оценки иммунного статуса // Клиническая лабораторная диагностика. 1994. № 3. С. 34-35.
3. Лучшев В.И., Санин Б.И., Жаров С.Н. Вирусный гепатит С - глобальная проблема нашего времени. // Рос. мед. журн. 2004. № 3. С. 40-45.
4. Собчак Д.М., Корочкина О.В. Оценка показателей Т-клеточного иммунитета и медиаторов иммунного ответа у больных хроническим гепатитом С // Эпидемиол. и инфекц. болезни. 2007. № 2. С. 37-42.
5. Учайкин В.Ф., Чуелов С.Б. Вирусные гепатиты у детей: от прошлого к настоящему // Детские инфекции. 2006. № 4. С. 4-8.
6. Ярилин А.А. Основы иммунологии. М.: Медицина, 1999. 608 с.
7. Chen M., Zhang D., Zhen W. et al. Characteristics of circulating T cell receptor gamma-delta T cells from individuals chronically infected with hepatitis B virus (HBV): an association between V (delta) 2 subtype and chronic HBV infection // J. Infect. Dis. 2008. Vol. 198, No. 11. P. 1643-1650.
8. Chen Y., Wei H., Sun R. et al. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells // Hepatology. 2007. Vol. 46, No. 3. P. 706-715.
9. Ergünay K., Gürakan F., Usta Y. et al. Detection of TT virus (TTV) by three frequently-used PCR methods targeting different regions of viral genome in children with cryptogenic hepatitis, chronic B hepatitis and hbs carriers // Turk. J. Pediatr. 2008. Vol. 50, No. 5. P. 432-437.
10. Ihan Hren N., Ihan A. T lymphocyte activation and cytokine expression in periapical granulomas and radicular cysts // Arch. Oral. Biol. 2009. Vol. 54, No. 2. P. 156-161.
11. Indolfi G., Bartolini E., Azzari C. et al. Intrafamilial transmission of hepatitis C virus: infection of the father predicts the risk of perinatal transmission // J. Med. Virol. 2008. Vol. 80, No. 11. P. 1907-1911.
12. Leonardi S., Rotolo N., Vitaliti G. et al. IgE values and T-lymphocyte subsets in children with atopic eczema/dermatitis syndrome // Allergy Asthma Proc. 2007. Vol. 28, No. 5. P. 529-534.
13. Martinez J., Huang X., Yang Y. Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo // J. Immunol. 2008. Vol. 180, No. 3. P. 1592-1597.
14. Shenoy A.R., Kim B.H., Choi H.P. et al. Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families // Immunobiology. 2007. Vol. 212, No. 9-10. P. 771-784.
15. You J., Sriplung H., Geater A. et al. Impact of viral replication inhibition by entecavir on peripheral T lymphocyte subpopulations in chronic hepatitis B patients // BMC Infect. Dis. 2008. Vol. 8. P. 123.
Review
For citations:
, , , Soloviova I.A., Savchenko A.A., Martyinova G.P. IMMUNE STATUS OF CHILDREN WITH CHRONIC VIRAL HEPATITIS B AND C. Pacific Medical Journal. 2010;(1):55-57. (In Russ.)
Views:
170
Email this article 