CLINICOPATHOLOGIC PROFILE OF HIV-INFECTED INFANTS HAVING A REALISED PERINATAL HIV-CONTACT AND EVALUATION OF TREATMENT EFFICIENCY

Abstract

The authors have observed 96 patients aged 1 month to 7 years who have perinatal contact with HIV-infection. Upon the attainment of the age of 18 months, 18 infants (18.8%) were diagnosed as having perinatal HIV-infection. Among significant factors defining the prognosis of progression and severity of infants' HIV-infection are burdened perinatal history (abuse of narcotics, abuse of alcohol, viral hepatitis), efficiency of prenatal prophylaxis, early antiretroviral treatment, recurrent severe respiratory infections and apparent dermatitis implications. Efficiency of highly active antiretroviral therapy in terms of standard and alternative regimens exceeded 80%. Structure of causes of HIV-infected infants' deaths based upon proprietary data gets in line with Russian statistics.