SIGNIFICANCE OF CYTOKINE STATUS IN EARLY DIAGNOSTICS OF TUBERCULOSIS ASSOCIATED WITH HIV-INFECTION
Abstract
HIV-positive patients and patients having HIV-infection associated with tuberculosis. The authors have studied dependency of detection probability for tuberculosis diagnosed in HIV-positive patients from initial levels of immunological profile at various stages of disease using stratification analysis. They also have performed logistic regression analysis with backward selection of predictors and detecting of tuberculosis contagion as dependent variable. Tuberculosis risk was dependent to a considerable extent on HIV RNA level, number of lymphocytes and length of tuberculosis preventive treatment. They have suggested a diagnostic search algorithm for early detection of tuberculosis in HIV-positive patients, which implies monitoring of ummunological markers (tumour-a necrosis factor, interleukin-10 and soluble receptor of interleukin-6) and their detection in certain intervals.
About the Authors
Е. Маркелова
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
С. Сотниченко
Краевой клинический центр по профилактике и борьбе со СПИД и инфекционными заболеваниями
Russian Federation
Russian Federation
Л. Скляр
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
E. V. Markelova
Vladivostok State Medical University
Russian Federation
Russian Federation
S. A. Sotnichenko
Regional Clinical Centre of Prevention and Fight against AIDS
Russian Federation
Russian Federation
L. F. Sklyar
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
, , , Markelova E.V., Sotnichenko S.A., Sklyar L.F. SIGNIFICANCE OF CYTOKINE STATUS IN EARLY DIAGNOSTICS OF TUBERCULOSIS ASSOCIATED WITH HIV-INFECTION. Pacific Medical Journal. 2009;(4):44-47. (In Russ.)
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