ANGIOGENIC AND CYTOPROTECTING EFFECTS OF BASIC FIBROBLAST GROWTH FACTOR IN FOCUS OF EXPERIMENTAL CEREBRAL ISCHEMIA
Abstract
Male-rat experiments using right general carotid ligation included simulation of cerebral ischemia and intra-arterial introduction of basic Fibroblast Growth Factor (control - physiological solution) and showed that bFGF has enhanced NADPH-diaphorase activity and endothelial proliferation in vessels and pericytes of pariental cerebral cortex. These processes corresponded to thickening of microvessels and reached their maximum after 12 days from ischemia. The paper discusses interaction between bFGF-dependent and nitroxidergic mechanisms of post-ischemic cerebrovascular re-organization. The authors believe stimulation of angiogenesis and maintenance of neuron viability against the bFGF introduction were indicative of decreasing toxic effects of nitric oxide in the focus of ischemia.
Keywords
616.831-005.4:612.084.6:546.172.6
About the Authors
С. Калиниченко
Владивостокский государственный университет экономики и сервиса
Russian Federation
Russian Federation
С. Щава
Краевая клиническая больница № 1
Russian Federation
Russian Federation
Н. Матвеева
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
S. G. Kalinichenko
Vladivostok State University of Economics and Service
Russian Federation
Russian Federation
S. P. Schava
Primorsky Regional
Clinical Hospital No.1
Russian Federation
Russian Federation
N. Yu. Matveeva
Vladivostok State Medical University
Russian Federation
Russian Federation
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Review
For citations:
, , , Kalinichenko S.G., Schava S.P., Matveeva N.Yu. ANGIOGENIC AND CYTOPROTECTING EFFECTS OF BASIC FIBROBLAST GROWTH FACTOR IN FOCUS OF EXPERIMENTAL CEREBRAL ISCHEMIA. Pacific Medical Journal. 2009;(2):66-69. (In Russ.)
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