Apoptosis of the synovial cells at patients with rheumatoid arthritis
Abstract
The samples of blood, synovia and synovial liquid at 78 patients with rheumatoid arthritis were investigated. Intensity of the apoptosis studied by TUNEL method (terminal deoxynucleotidil transferasemediated dUTP nick endlabeling), based on revealing of the fragmentized DNA chains. Intensity of programmed cellular death of synovial cells depend on balance of anti- and pro-apoptotic molecules on morphological (Bcl2 and p53) and humoral (sFas) levels. The received results specify low apoptosis intensity at early stage and its significant activization at late stages rheumatoid arthritis. In process of disease progressing the morphological structure of the apoptotic structures was changed to fibroblasts of stromal layer of the hypertrophied synovia.
About the Authors
А. Дубиков
Городская клиническая больница № 2
Russian Federation
Russian Federation
A. I. Dubikov
Russian Federation
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Review
For citations:
, Dubikov A.I. Apoptosis of the synovial cells at patients with rheumatoid arthritis. Pacific Medical Journal. 2008;(4):20-22. (In Russ.)
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