The role of the nitroxidergic mechanisms in the development of the adjuvant arthritis
Abstract
- Immune cytochemichal method was used in investigation of localization and activity of the nitro-oxidsyntases in synovial cells on model of rheumatoid arthritis at 30 experimental animals at different stages of inflammatory process. Direct participation of the nitroxidergic mechanisms in the development of the adjuvant arthritis is found. The specified mechanisms are determined by synovial cells function, in which nitro-oxidsyntases activity was non-uniform: prevalence of the induced forms in acute phase on a background of permanent synthesis of the neuronal form in acute and chronic phases, that, probably, can play role in transformation of acute arthritis into chronic
Keywords
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About the Authors
Л. Белоголовых
Городская клиническая больница № 2
Russian Federation
Russian Federation
А. Дубиков
Городская клиническая больница № 2
Russian Federation
Russian Federation
Е. Медведь
Городская клиническая больница № 2
Russian Federation
Russian Federation
И. Гришина
Городская клиническая больница № 2
Russian Federation
Russian Federation
О. Любарская
Городская клиническая больница № 2
Russian Federation
Russian Federation
Т. Кабанцева
Городская клиническая больница № 2
Russian Federation
Russian Federation
Е. Борисенко
Владивостокский государственный медицинский университет
Russian Federation
Russian Federation
L. A. Belogolovyh
Russian Federation
A. I. Dubikov
Russian Federation
E. E. Medved
Russian Federation
I. E. Grishina
Russian Federation
O. A. Lyubarskaya
Russian Federation
T. A. Kabantseva
Russian Federation
E. A. Borisenko
Russian Federation
References
1. Дубиков А.И. Ревматоидный артрит, апоптоз, оксид азота. Новые аспекты патогенеза. - Владивосток, 2004.
2. Копьева Т.Н., Веникова М.С. Клиническая морфология артритов при ревматических заболеваниях. - М. : РАМН, 1992.
3. Плесковская Г.Н. // Ревматология. - 1991. - № 4. - С. 38-44.
4. Покровский В.И., Виноградов Н.А. // Тер. архив. - 2005. - № 1. - С. 82-87.
5. Сосунов А.А. // Соросовский образовательный журн. - 2000. - Т. 6, № 12. - С. 27-34.
6. Cannon G.W., Oppenshaw S.J., Hibbs J.B. et al. // Arthritis Rheum. - 1996. - Vol. 39. - P. 1677-1684.
7. Chillingworth N.L., Donaldson L.F. // J. Neurosci. Methods. - 2003. - Vol. 128, No. 1-2. - P. 45-52.
8. Connor J.A., Manning P.T., Settle S.L. et al. // Eur. J. Pharmacol. - 1995. - Vol. 273. - P. 15-24.
9. Grabowski P.S., Macpherson H., Ralston S.H. // Br. J. Rheum. - 1996. - Vol. 35. - P. 207-212.
10. Hope B.T., Vincent S.R. // J. Histochem. Cytochem. - 1989. - Vol. 37, No. 5. - Р. 653-661.
11. Ishiuchi N., Yoshino S., Yokoyama M. et al. // Ryuma- chi. - 1999. - Vol. 39, No. 5. - P. 749-756.
12. McCartney-Francis N.L., Song X., Mizel D.E. et al. // J. Immunol. - 2001. - Vol. 166, No. 4. - P. 2734-2740.
13. Onur O., Akinci A.S., Akbiyik F. et al. // Rheum. Int. - 2001. - Vol. 20, No. 4. - P. 154-158.
14. Rediske J., Koehne C., Zhang B. et al. // Osteaarthritis Cart. - 1994. - Vol. 2. - P. 199-206.
15. Robert Clancy M., Amin Ashok R., Steven Abramson B. // Arthritis Rheum. -1998. - Vol. 41, No. 7. - P. 1141-1151.
Review
For citations:
, , , , , , , Belogolovyh L.A., Dubikov A.I., Medved E.E., Grishina I.E., Lyubarskaya O.A., Kabantseva T.A., Borisenko E.A. The role of the nitroxidergic mechanisms in the development of the adjuvant arthritis. Pacific Medical Journal. 2008;(4):39-40. (In Russ.)
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